Proton-Pump Inhibitor as Palliative Care for Chemotherapy-Induced Gastroesophageal Reflux Disease in Pancreatic Cancer Patients

被引：11

作者：

Uwagawa, Tadashi ^{[1
]}

Misawa, Takeyuki ^{[1
]}

Iida, Tomonori ^{[1
]}

Sakamoto, Taro ^{[1
]}

Gocho, Takeshi ^{[1
]}

Wakiyama, Shigeki ^{[1
]}

Hirohara, Shoichi ^{[1
]}

Yanaga, Katsuhiko ^{[1
]}

机构：

[1] Jikei Univ, Sch Med, Dept Surg, Tokyo, Japan

来源：

JOURNAL OF PALLIATIVE MEDICINE | 2010年 / 13卷 / 07期

关键词：

RECOMMENDATIONS; GUIDELINES; THERAPY;

D O I：

10.1089/jpm.2009.0404

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Relief of adverse events induced by chemotherapy is an important issue for patients, especially those with a poor prognosis, such as with pancreatic cancer. There are no reports of the relationship between gastroesophageal reflux disease (GERD) and chemotherapy, so we investigated the incidence of chemotherapy-induced GERD in patients undergoing treatment with gemcitabine or S-1 for pancreatic cancer and the effect of sodium rabeprazole (RPZ), a proton-pump inhibitor. GERD was diagnosed in 40% of the patients according to the Frequency Scale for Symptoms of GERD score, and RBZ therapy significantly improved their symptoms.

引用

页码：815 / 818

页数：4

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