Sonochemical fabrication of folic acid functionalized multistimuli-responsive magnetic graphene oxide-based nanocapsules for targeted drug delivery

被引：41

作者：

Cui, Xuejun ^{[1
]}

Dong, Linlin ^{[1
]}

Zhong, Shuangling ^{[2
]}

Shi, Chao ^{[1
]}

Sun, Yuexin ^{[1
]}

Chen, Peng ^{[3
]}

机构：

[1] Jilin Univ, Coll Chem, 2699 Qianjin St, Changchun 130012, Jilin, Peoples R China

[2] Jilin Agr Univ, Coll Resources & Environm Sci, 2888 Xincheng St, Changchun 130118, Jilin, Peoples R China

[3] Nanyang Technol Univ, Sch Chem & Biomed Engn, 70 Nanyang Dr, Singapore 637457, Singapore

来源：

CHEMICAL ENGINEERING JOURNAL | 2017年 / 326卷

基金：

中国国家自然科学基金;

关键词：

Folic acid; Magnetic; Nanocapsule; Multi-stimuli responsive; Sonochemical; Targeted drug delivery; PROTEINACEOUS MICROSPHERES; MULTILAYER CAPSULES; THIOLATED CHITOSAN; MICROCAPSULES; REDOX; NANOPARTICLES; MICELLES; RELEASE; THERAPY; SYSTEMS;

D O I：

10.1016/j.cej.2017.06.045

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A novel folic acid (FA) functionalized multistimuli-responsive magnetic graphene oxide (GO)-based nanocapsules (FA-MRMGONCs) were designed as a targeted drug carrier. The FA-MRMGONCs were obtained successfully from thiolated GO (TGO) and FA functionalized thiolated chitosan (FA-CS-SH) via sonochemical approach. FA-MRMGONCs were endowed with photothermal properties from GO. The hydrosulfuryl groups (-SH) of TGO and FA-CS-SH would be cross-linked to form the disulfide bonds under sonication. The disulfide bonds could be broken under reductive trigger and showed excellent reductive responsiveness to control drugs release. The oleic acid modified Fe3O4 NPs (OA-Fe3O4 NPs) were encapsulated into the FA-MRMGONCs and endowed FA-MRMGONCs with favorable magnetic guide functionality. Moreover, FA-MRMGONCs showed attractive FA-receptor-mediated targeting ability to the FA-receptors (FRs) positive cells due to the immobilization of FA on FA-MRMGONCs. The novel FA-MRMGONCs could be a promising smart nanocarrier for targeted delivery and triggered release of hydrophobic drugs for the cancer therapy in biomedical applications. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：839 / 848

页数：10

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