Molecular detection of extensively drug-resistant Salmonella Typhi and carbapenem-resistant pathogens in pediatric septicemia patients in Pakistan - a public health concern

被引：9

作者：

Qamar, Muhammad Usman ^{[1
]}

Ambreen, Atifa ^{[1
]}

Batool, Alia ^{[2
]}

Rasool, Muhammad Hidayat ^{[1
]}

Shafique, Muhammad ^{[1
]}

Khan, Adnan ^{[3
]}

Nisar, Muhammad Atif ^{[1
,4
]}

Khalid, Anam ^{[2
]}

Junaid, Kashaf ^{[5
]}

Abosalif, Khalid O. A. ^{[5
]}

Ejaz, Hasan

机构：

[1] Govt Coll Univ Faisalabad, Fac Life Sci, Dept Microbiol, Faisalabad 38000, Pakistan

[2] Fatima Mem Hosp, Dept Pathol, Lahore 54000, Pakistan

[3] Univ Karachi, Dept Microbiol, Karachi, Pakistan

[4] Flinders Univ S Australia, Coll Sci Engn, Adelaide, SA, Australia

[5] Jouf Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Al Jouf 72388, Saudi Arabia

来源：

FUTURE MICROBIOLOGY | 2020年 / 16卷 / 10期

关键词：

carbapenem-resistant; children; septicemia; XDR Salmonella Typhi; BLOOD-STREAM INFECTIONS; KLEBSIELLA-PNEUMONIAE; ANTIMICROBIAL SUSCEPTIBILITY; UNITED-STATES; HOSPITALS; CHILDREN; PATTERN; BURDEN;

D O I：

10.2217/fmb-2021-0036

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: To determine the prevalence of multidrug (MDR) and extensively drug-resistant (XDR) pathogens from pediatric blood samples Methods: In total, 4543 children's blood samples were processed in the BacT/ALERT system. Confirmation of the isolates and MIC was determined in VITEK 2 system. Molecular identification of bla(IMP), bla(VIM) and bla(OXA-48) was done by PCR. Results: Of 4543 blood cultures, 458 (10%) were positive for bacterial growth and Salmonella Typhi (415; 90%) remained the primary pathogens. Antibiogram revealed 208 (50.1%) and 137 (33%) were MDR and XDR S. Typhi, respectively. Klebsiella pneumoniae displayed 46% resistance to imipenem. One hundred twelve (81.7%) XDR Typhi were positive for bla(CTXM), whereas 14 (66.6%) bla(VIM) were found in carbapenem-resistant bacteria. Conclusion: A high prevalence of MDR and XDR pathogens was found in peads blood culture.

引用

页码：731 / 739

页数：9

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