The role of Th17 cells: explanation of relationship between periodontitis and COPD?

被引：15

作者：

Liu, Jiaohong ^{[1
,2
]}

Ouyang, Yuanting ^{[1
,2
]}

Zhang, Zhiyi ^{[1
,2
]}

Wen, Siyi ^{[1
,2
]}

Pi, Yixing ^{[1
,2
]}

Chen, Ding ^{[1
,2
]}

Su, Zhikang ^{[1
,2
]}

Liang, Zitian ^{[1
,2
]}

Guo, Lvhua ^{[1
,2
]}

Wang, Yan ^{[1
,3
]}

机构：

[1] Guangzhou Med Univ, Guangzhou, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Guangdong Engn Res Ctr Oral Restorat & Reconstruc, Guangzhou Key Lab Basic & Appl Res Oral Regenerat, Dept Prosthodont,Affiliated Stomatol Hosp, Guangzhou, Guangdong, Peoples R China

[3] First Affiliated Hosp, Guangzhou Inst Resp Hlth, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China

来源：

INFLAMMATION RESEARCH | 2022年 / 71卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Periodontitis; COPD; Th17; cells; Inflammatory cytokines; Soft tissue destruction; OBSTRUCTIVE PULMONARY-DISEASE; GINGIVAL CREVICULAR FLUID; ENHANCES CCL20 PRODUCTION; T-CELLS; TGF-BETA; PORPHYROMONAS-GINGIVALIS; MATRIX-METALLOPROTEINASE; SALIVARY BIOMARKERS; INTERLEUKIN; 17A; GENE-EXPRESSION;

D O I：

10.1007/s00011-022-01602-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Periodontitis and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases with common risk factors, such as long-term smoking, age, and social deprivation. Many observational studies have shown that periodontitis and COPD are correlated. Moreover, they share a common pathophysiological process involving local accumulation of inflammatory cells and cytokines and damage of soft tissues. The T helper 17 (Th17) cells and the related cytokines, interleukin (IL)-17, IL-22, IL-1 beta, IL-6, IL-23, and transforming growth factor (TGF)-beta, play a crucial regulatory role during the pathophysiological process. This paper reviewed the essential roles of Th17 lineage in the occurrence of periodontitis and COPD. The gaps in the study of their common pathological mechanism were also evaluated to explore future research directions. Therefore, this review can provide study direction for the association between periodontitis and COPD and new ideas for the clinical diagnosis and treatment of the two diseases.

引用

页码：1011 / 1024

页数：14

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