Cancer stem cells in breast: Current opinion and future challenges

被引：129

作者：

Charafe-Jauffret, Emmanuelle ^{[1
,2
,3
]}

Monville, Florence

Ginestier, Christophe ^{[4
]}

Dontu, Gabriela ^{[4
]}

Birnbaum, Daniel

Wicha, Max S. ^{[4
]}

机构：

[1] Univ Aix Marseille 2, Inst J Paoli I Calmettes, Dept Mol Oncol, Ctr Rech Cancerol Marseille,INSERM,UMR891, FR-13273 Marseille 09, France

[2] Univ Aix Marseille 2, Inst J Paoli I Calmettes, Dept Biopathol, FR-13273 Marseille 09, France

[3] Univ Aix Marseille 2, Fac Med, FR-13273 Marseille 09, France

[4] Univ Michigan, Med Ctr, Dept Internal Med, Div Hematol Oncol,Comprehens Can Ctr, Ann Arbor, MI 48109 USA

来源：

PATHOBIOLOGY | 2008年 / 75卷 / 02期

关键词：

breast cancer; stem cell; targeted therapy; aldehyde dehydrogenase;

D O I：

10.1159/000123845

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is increasing evidence for the cancer stem cell hypothesis, which holds that cancers are driven by a cellular sub-component that has stem cell properties, that is, self-renewal, tumorigenicity and multilineage differentiation capacity. The cancer stem cell hypothesis modifies our conceptual approach of oncogenesis and shall have implications in breast cancer prevention, detection and treatment, especially in metastatic breast cancer for which no curative treatment exists. Given the specific stem cell features, novel therapeutic pathways can be targeted. Following this approach, new molecules are currently in development. Focusing on the cross-talk between stem cells and their microenvironment is also a promising way to explore how to better target cancer stem cells and be curative. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：75 / 84

页数：10

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