Rab5 and Rac team up in cell motility

被引：12

作者：

Zech, Tobias ^{[1
]}

Machesky, Laura ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

CELL | 2008年 / 134卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.cell.2008.06.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamidessi et al. (2008) show that Rab5-directed trafficking of Rac to the cell membrane is required for Rac-mediated actin assembly. Trafficking of Rac may influence the mode of cell migration during morphogenesis and cancer metastasis.

引用

页码：18 / 20

页数：4

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