Genetics of Epstein-Barr virus infection

被引:3
作者
Hiraki, A [1 ]
Fujii, N [1 ]
Masuda, K [1 ]
Ikeda, K [1 ]
Tanimoto, M [1 ]
机构
[1] Okayama Univ, Sch Med, Dept Med 2, Okayama 7008558, Japan
关键词
Epstein-Barr virus; immune response; latent infection; replication;
D O I
10.1016/S0753-3322(01)00084-1
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Epstein-Barr (EBV) virus is a member of the human herpesvirus family. EBV is the etiologic agent of acute infectious mononucleosis and is closely associated with the genesis of Burkitt's lymphoma and undifferentiated nasopharyngeal carcinoma. EBV is also implicated in a variety of other diseases, such as X-linked lymphoproliferative syndrome, T-cell non-Hodgkin's lymphoma, Hodgkin's disease, and NK-cell granular lymphoproliferative disorder. Recently, lymphoepithelial carcinoma of the stomach, gastric carcinoma, pyothorax-associated lymphoma, and smooth muscle tumors were also recognized as EBV-associated diseases. It is therefore important to review the genetics and immunological response of EBV infection. In this review we summarize the genetics of EBV, immunological responses and clinical findings of EBV-associated diseases, which would help us to understand the pathophysiology of EBV-associated disease and develop specific treatments. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:369 / 372
页数:4
相关论文
共 50 条
[1]   The immunology of Epstein-Barr virus infection [J].
Moss, DJ ;
Burrows, SR ;
Silins, SL ;
Misko, I ;
Khanna, R .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 2001, 356 (1408) :475-488
[2]   Genetics of Epstein-Barr virus microRNAs [J].
Klinke, Olaf ;
Feederle, Regina ;
Delecluse, Henri-Jacques .
SEMINARS IN CANCER BIOLOGY, 2014, 26 :52-59
[3]   Serum Epstein-Barr virus DNA load in primary Epstein-Barr virus infection [J].
Bauer, CC ;
Aberle, SW ;
Popow-Kraupp, T ;
Kapitan, M ;
Hofmann, H ;
Puchhammer-Stöckl, E .
JOURNAL OF MEDICAL VIROLOGY, 2005, 75 (01) :54-58
[4]   Hemoptysis and Epstein-Barr virus infection [J].
Weinstein, M ;
O'Hare, B .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (08) :759-760
[5]   Primary Epstein-Barr virus infection [J].
Dunmire, Samantha K. ;
Verghese, Priya S. ;
Balfour, Henry H., Jr. .
JOURNAL OF CLINICAL VIROLOGY, 2018, 102 :84-92
[6]   Epstein-Barr virus infection: the micro and macro worlds [J].
Huang, Wei ;
Bai, Lang ;
Tang, Hong .
VIROLOGY JOURNAL, 2023, 20 (01)
[7]   Epstein-Barr Virus Infection and Posttransplant Lymphoproliferative Disorder [J].
Green, M. ;
Michaels, M. G. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 :41-54
[8]   Epstein-Barr Virus Infection and Multiple Sclerosis: A Review [J].
Ascherio, Alberto ;
Munger, Kassandra L. .
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2010, 5 (03) :271-277
[9]   EPSTEIN-BARR VIRUS LOAD IN CEREBROSPINAL FLUID OF PATIENTS WITH CHRONIC ACTIVE EPSTEIN-BARR VIRUS INFECTION [J].
Ohga, Shouichi ;
Sanefuji, Masafumi ;
Ishimura, Masataka ;
Nomura, Akihiko ;
Torisu, Hiroyuki ;
Kira, Ryutaro ;
Takada, Hidetoshi ;
Mizuno, Yumi ;
Kazuyama, Yukumasa ;
Hara, Toshiro .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2008, 27 (11) :1027-1030
[10]   Quantification of Epstein-Barr Virus DNA Is Helpful for Evaluation of Chronic Active Epstein-Barr Virus Infection [J].
Sakamoto, Yuichi ;
Mariya, Yasushi ;
Kubo, Kohmei .
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 227 (04) :307-311