Addition of C-nucleophiles to 5-phenylpyrimidin-2(1H)-ones and 6-phenyl-1,2,4-triazin-3(2H)-one

被引：3

作者：

Egorov, Ilya N. ^{[1
]}

Tseitler, Tatyana A. ^{[1
]}

Zyryanov, Grigory V. ^{[1
,2
]}

Rusinov, Vladimir L. ^{[1
]}

Chupakhin, Oleg N. ^{[1
,2
]}

机构：

[1] Ural Fed Univ, Dept Organ Chem, Mira St 19, Ekaterinburg 620002, Russia

[2] Russian Acad Sci, Inst Organ Synth, Ural Branch, Ekaterinburg 620041, Russia

来源：

ARKIVOC | 2011年

关键词：

Pyrimidinones; 1,2,4-triazinones; indoles; nucleophilic addition reactions; aza-Friedel-Crafts reactions; FRIEDEL-CRAFTS REACTION; 2-PYRIMIDINONE NUCLEOSIDES; AROMATIC-SUBSTITUTION; BIOLOGICAL-ACTIVITIES; ANTIVIRAL ACTIVITY; IDENTIFICATION; PYRIMIDINE; ANALOGS; PURINE;

D O I：

10.3998/ark.5550190.0012.a26

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Addition reactions of C-nucleophiles to the C=N bond of 5-phenyl- and 1-methyl-5-phenylpyrimidin-2(1H)-ones 1a,b and 6-phenyl-1,2,4-triazin-3(2H)-one 2 were investigated. 1a, b and 2 furnished addition products with indoles; 1a also added N-methylpyrrole. Only 2 added thiophene and methyl ketones, and reacted with alkyl halides and acetone forming products resulting both from alkylation and from addition of acetone at positions 2 and 5, respectively.

引用

页码：323 / 334

页数：12

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