Gastrokinetic effect of ghrelin analog RC-1139 in the rat - Effect on post-operative and on morphine induced ileus

被引：38
作者：
Poitras, P
Polvino, WJ
Rocheleau, B
机构：
[1] Univ Montreal, Hop St Luc, CHUM, Ctr Rech, Montreal, PQ H2X 1P1, Canada
[2] Rejuvenon Corp, The Woodlands, TX USA
来源：
PEPTIDES | 2005年 / 26卷 / 09期
关键词：
regulatory peptide; peptide; gastrointestinal motility; gastric emptying; opiates;
D O I：
10.1016/j.peptides.2005.02.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We aimed to confirm the gastrokinetic effect of ghrelin analog, RC-1139, in the presence of opiates. Gastric emptying was verified in rats by counting stomach residue 15 min after gavage of methylcellulose. Normal rats: RC- 1139 (0, 0.25, 1.0, 2.5 mg/kg i.v.) decreased methylcellulose left in stomach (47, 36, 12, 10% of ingested solution). Post-operative ileus (post-op. ileus) ileus: gastric residue decreased from 88 to 66, 53, 51% with RC-1139 0, 1.0, 2.5, 10 mg/kg. Morphine in post-op. ileus: gastroparesis was corrected at 10 mg/kg (54%). Ghrelin analog RC-1139 is a potent gastrokinetic in rat; it reversed gastric post-op. ileus, even in the presence of opiates. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：1598 / 1601
页数：4
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