Ru(II)-based antineoplastic: A "wingtip" N-heterocyclic carbene facilitates access to a new class of organometallics that are cytotoxic to common cancer cell lines

被引：17

作者：

Mondal, Ambarish ^{[1
]}

Tripathy, Rajat K. ^{[1
]}

Dutta, Parul ^{[2
]}

Santra, Manas Kumar ^{[2
]}

Isab, Anvarhusein A. ^{[3
]}

Bielawski, Christopher W. ^{[4
,5
,6
]}

Kisan, Hemanta K. ^{[1
]}

Chandra, Swapan K. ^{[7
]}

Dinda, Joydev ^{[1
]}

机构：

[1] Utkal Univ, Dept Chem, Bhubaneswar 751004, Odisha, India

[2] Natl Ctr Cell Sci, Pune 411007, Maharashtra, India

[3] King Fahd Univ Petr & Minerals, Dept Chem, Dhahran 31261, Saudi Arabia

[4] IBS, CMCM, Ulsan 44919, South Korea

[5] UNIST, Dept Chem, Ulsan 44919, South Korea

[6] UNIST, Dept Energy Engn, Ulsan 44919, South Korea

[7] Visva Bharati Univ, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2019年 / 33卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

cytotoxicity; Gold(I)-NHC; N-heterocyclic carbene; silver(I)-NHC; GOLD(III) COMPLEXES; RUTHENIUM COMPLEXES; NATURAL-PRODUCTS; ANTICANCER; AG(I); NHC; INHIBITORS; APOPTOSIS; SILVER(I); AGENTS;

D O I：

10.1002/aoc.4692

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The syntheses, structures, and chemotherapeutic activities of Ag(I)-, Au(I)-, and Ru(II)-complexes ligated to a novel N-heterocyclic carbene ligand, 2-(4-nitrophenyl)imidazo[1,5-a]pyridin-2-ylidene (1), are described. The corresponding complexes, [Ag(1)(2)][PF6], [Au(1)(2)][PF6] (3), and [Ru(1)(p-cymene)Cl][PF6] (4), were prepared using convenient transmetallation chemistry and characterized using a range of spectroscopic and analytical techniques. X-ray crystallography revealed that complexes 2 and 3 adopted linear structures whereas 4 exhibited a prototypical "piano-stool"-like geometry; the structural assignments were further supported by DFT calculations. A series of in vitro studies revealed that while the aforementioned Ag(I), Au(I) and Ru(II) complexes exhibited significant cytotoxicities against the human colon adenocarcinoma (HCT 116), lung cancer (A549), and breast cancer (MCF7) cell lines, the Ru derivative was most prominent.

引用

页数：14

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