A Biocatalytic Aza-Achmatowicz Reaction

被引：45

作者：

Fernandez-Fueyo, Elena ^{[1
]}

Younes, Sabry H. H. ^{[1
,2
]}

van Rootselaar, Stefan ^{[3
]}

Aben, Rene W. M. ^{[3
]}

Renirie, Rokus ^{[4
]}

Wever, Ron ^{[5
]}

Holtmann, Dirk ^{[6
]}

Rutjes, Floris P. J. T. ^{[3
]}

Hollmann, Frank ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Biotechnol, Julianalaan 136, NL-2628 BL Delft, Netherlands

[2] Sohag Univ, Dept Chem, Fac Sci, Sohag 82524, Egypt

[3] Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

[4] IVAM UvA BV, Plantage Muidergracht 24, NL-1018 TV Amsterdam, Netherlands

[5] Univ Amsterdam, Vant Hoff Inst Mol Sci HIMS, Fac Sci, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands

[6] DECHEMA Res Inst, Theodor Heuss Allee 25, D-60486 Frankfurt, Germany

来源：

ACS CATALYSIS | 2016年 / 6卷 / 09期

关键词：

Achmatowicz reaction; biocatalysis; hypohalogenites; oxidation; peroxidase; VANADIUM CHLOROPEROXIDASE; CURVULARIA-INAEQUALIS; OXYFUNCTIONALIZATION REACTIONS; PIPERIDINONES; OXIDATION; ENTRY;

D O I：

10.1021/acscatal.6b01636

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A catalytic, enzyme-initiated (aza-) Achmatowicz reaction is presented. The involvement of a robust vanadium-dependent peroxidase from Curvularia inaequalis allows the simple use of H2O2 and catalytic amounts of bromide.

引用

页码：5904 / 5907

页数：4

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