Therapeutic interventions targeting the nitric oxide system: Current and potential uses in obstetrics, bone disease and erectile dysfunction

被引:7
作者
Grant, MKO [1 ]
El-Fakahany, EE [1 ]
机构
[1] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA
关键词
nitric oxide; rheumatoid arthritis; osteoporosis; preterm labor; cervical ripening; erectile dysfunction;
D O I
10.1016/j.lfs.2003.08.029
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Nitric oxide is involved in a countless number of physiological processes and is known to have cytoprotective as well as cytotoxic effects. Increased knowledge about the multifaceted role of nitric oxide in a variety of disease states has led to the design of multiple treatment strategies involving the nitric oxide system. The current review focuses on recent research advances in the fields of obstetrics, bone disease and erectile dysfunction that have led to current or potential future therapies involving nitric oxide. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:1701 / 1721
页数:21
相关论文
共 191 条
  • [21] Evidence for the involvement of endothelial nitric oxide synthase from smooth muscle cells in the erectile function of the human corpus cavernosum
    Bloch, W
    Klotz, T
    Sedlaczek, P
    Zumbe, J
    Engelmann, U
    Addicks, K
    [J]. UROLOGICAL RESEARCH, 1998, 26 (02): : 129 - 135
  • [22] Borderie D, 1999, J RHEUMATOL, V26, P2083
  • [23] BIDIRECTIONAL REGULATION OF OSTEOCLAST FUNCTION BY NITRIC-OXIDE SYNTHASE ISOFORMS
    BRANDI, ML
    HUKKANEN, M
    UMEDA, T
    MORADIBIDHENDI, N
    BIANCHI, S
    GROSS, SS
    POLAK, JM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) : 2954 - 2958
  • [24] NITRIC-OXIDE - A PHYSIOLOGICAL MESSENGER MOLECULE
    BREDT, DS
    SNYDER, SH
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 : 175 - 195
  • [25] BRENNAN FM, 1989, LANCET, V2, P244
  • [26] NITRIC-OXIDE SYNTHASE - A NEW DIAGNOSTIC-TOOL FOR NEUROGENIC IMPOTENCE
    BROCK, G
    NUNES, L
    PADMANATHAN, H
    BOYD, S
    LUE, TF
    [J]. UROLOGY, 1993, 42 (04) : 412 - 417
  • [27] Efficacy and safety of tadalafil for the treatment of erectile dysfunction: Results of integrated analyses
    Brock, GB
    McMahon, CG
    Chen, KK
    Costigan, T
    Shen, W
    Watkins, V
    Anglin, G
    Whitaker, S
    [J]. JOURNAL OF UROLOGY, 2002, 168 (04) : 1332 - 1336
  • [28] INVOLVEMENT OF A NITRIC OXIDE-CYCLIC GUANOSINE-MONOPHOSPHATE PATHWAY IN CONTROL OF HUMAN UTERINE CONTRACTILITY DURING PREGNANCY
    BUHIMSCHI, I
    YALLAMPALLI, C
    DONG, YL
    GARFIELD, RE
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1995, 172 (05) : 1577 - 1584
  • [29] Buhimschi I, 1996, HUM REPROD, V11, P1755
  • [30] Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase
    Burnett, AL
    Nelson, RJ
    Calvin, DC
    Liu, JX
    Demas, GE
    Klein, SL
    Kriegsfeld, LJ
    Dawson, VL
    Dawson, TM
    Snyder, SH
    [J]. MOLECULAR MEDICINE, 1996, 2 (03) : 288 - 296