A solid phase approach to oligomers of carbohydrate amino-acids: Secondary structure in a trimeric furanose carbopeptoid

被引：42
作者：
Long, DD
Smith, MD
Marquess, DG
Claridge, TDW
Fleet, GWJ
机构：
[1] Oxford Ctr Mol Sci, Dyson Perrins Lab, Oxford OX1 3QY, England
[2] Glaxo Wellcome Med Res Ctr, Stevenage SG1 2NY, Herts, England
[3] Adv Med Inc, San Francisco, CA 94080 USA
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 50期
关键词：
D O I：
10.1016/S0040-4039(98)02089-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of oligomers of a C-arabinofuranosyl carbohydrate amino acid on a polystyrene support functionalised with a Pink linker is reported. Cleavage from the solid support gives ready access to dimeric and trimeric carbopeptoids bearing a C-terminal carboxamide. Investigations into the solution structure of these novel carbopeptoids utilising H-1 NMR indicate that they adopt well defined conformations based around a repeating beta-turn like structure stabilised by (i, i-2) inter-residue hydrogen bonds. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：9293 / 9296
页数：4
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