Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes

被引:38
作者
Rivellese, Angela A. [1 ]
Giacco, Rosalba [2 ]
Annuzzi, Giovanni [1 ]
De Natale, Claudia [1 ]
Patti, Lidia [1 ]
Di Marino, Lucrezia [1 ]
Minerva, Valentina [1 ]
Costabile, Giuseppina [1 ]
Santangelo, Carmela [3 ]
Masella, Roberta [3 ]
Riccardi, Gabriele [1 ]
机构
[1] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy
[2] CNR, Inst Food Sci, Avellino, Italy
[3] Natl Ctr Food Qual & Risk Assessment, Ist Super Sanita, Rome, Italy
关键词
type; 2; diabetes; dietary fat; postprandial lipoproteins; insulin resistance; adipose tissue lipases;
D O I
10.1016/j.clnu.2007.07.005
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: The effects of different dietary fatty acids on postprandial lipid metabolism in type 2 diabetic patients are still debated. Aim: To evaluate the effects of monounsaturated (MUFA) vs. saturated fat (SAFA)-rich diets on postprandial lipemia and adipose tissue lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in type 2 diabetes. Materials and methods: Eleven type 2 diabetic patients followed, in random order, a diet rich in MUFA (SAFA 8%, MUFA 23%) and another rich in SAFA (SAFA 17%, MUFA 15%) for a period of 3 weeks each. At the end of the two diets, a standard fat-rich meat was administered and subcutaneous fat biopsies were performed at fasting and 6h after the test meat. Results: Neither diet induced significant changes in meat lipid tolerance, except for a faster (at 2 h) increase in chytomicron triglycerides and a significant decrease in small VLDL triglyceride incremental area after the MUFA diet (-13.6 +/- 4.7mg/dl*6h vs. -2.2 +/- 3.7mg/dl*6h, p<0.005) (M +/- SEM). LPL and HSL activities were significantly increased after the MUFA diet. Conclusions: A MUFA-rich diet reduces postprandial small VLDL triglycerides in type 2 diabetic patients compared to a SAFA-rich diet, and modifies lipolytic enzymes in adipose tissue. (C) 2007 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. ALL rights reserved.
引用
收藏
页码:133 / 141
页数:9
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