The role of blood-brain barrier permeability in brain tumor imaging and therapeutics

被引：70
作者：
Provenzale, JM
Mukundan, S
Dewhirst, M
机构：
[1] Duke Univ, Med Ctr, Durham, NC 27710 USA
[2] Duke Univ, Dept Radiat Oncol, Med Ctr, Durham, NC 27710 USA
来源：
AMERICAN JOURNAL OF ROENTGENOLOGY | 2005年 / 185卷 / 03期
关键词：
D O I：
10.2214/ajr.185.3.01850763
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
OBJECTIVE. Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes. CONCLUSION. Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.
引用
收藏
页码：763 / 767
页数：5
相关论文
共 29 条
[1]   The blood-brain barrier and oncology: new insights into function and modulation [J].
Bart, J ;
Groen, HJM ;
Hendrikse, NH ;
van der Graaf, WTA ;
Vaalburg, W ;
de Vries, EGE .
CANCER TREATMENT REVIEWS, 2000, 26 (06) :449-462
[2]  
Bartus R T, 1999, Curr Opin Drug Discov Devel, V2, P152
[3]   Assessing tumor angiogenesis using macromolecular MR imaging contrast media [J].
Brasch, R ;
Pham, C ;
Shames, D ;
Roberts, T ;
vanDijke, K ;
vanBruggen, N ;
Mann, J ;
Ostrowitzki, S ;
Melnyk, O .
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1997, 7 (01) :68-74
[4]   Functional tumor imaging with dynamic contrast-enhanced magnetic resonance imaging [J].
Choyke, PL ;
Dwyer, AJ ;
Knopp, MV .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2003, 17 (05) :509-520
[5]   Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals [J].
Dewhirst, MW ;
Shan, S ;
Cao, YT ;
Moeller, B ;
Yuan, F ;
Li, CY .
DISEASE MARKERS, 2002, 18 (5-6) :293-311
[6]  
FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182
[7]   Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to anti-angiogenic therapy in a xenograft model of glioblastoma multiforme [J].
Gossmann, A ;
Helbich, TH ;
Kuriyama, N ;
Ostrowitzki, S ;
Roberts, TPL ;
Shames, DM ;
van Bruggen, N ;
Wendland, MF ;
Israel, MA ;
Brasch, RC .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2002, 15 (03) :233-240
[8]   A comparison of Ktrans measurements obtained with conventional and first pass pharmacokinetic models in human gliomas [J].
Haroon, HA ;
Buckley, DL ;
Patankar, TA ;
Dow, GR ;
Rutherford, SA ;
Balériaux, D ;
Jackson, A .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2004, 19 (05) :527-536
[9]   BARRIERS TO DRUG-DELIVERY IN SOLID TUMORS [J].
JAIN, RK .
SCIENTIFIC AMERICAN, 1994, 271 (01) :58-65
[10]  
Kong G, 2001, CANCER RES, V61, P3027
123