The relationship of transforming growth factor-β and lung cancer

被引：0

作者：

Xue, Xinying ^{[1
,2
]}

Zhao, Sheng ^{[3
]}

Zhang, Zhenning ^{[2
]}

Wang, Yamei ^{[2
]}

Chang, Yan ^{[4
]}

Xu, Yali ^{[2
]}

Jiang, Hong ^{[2
]}

Ma, Xiaorong ^{[2
]}

Qian, Jin ^{[2
]}

Guo, Rui ^{[2
]}

Wang, Kaifei

Yao, Xiaoyan ^{[2
]}

Gao, Peiliang ^{[2
]}

Deng, Hui ^{[2
]}

Zhang, Mingyue ^{[1
]}

Ao, Ting ^{[1
]}

Lang, Shan ^{[1
]}

Pan, Lei ^{[2
]}

Wang, Jianxin ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Resp Dis, Fuxing Rd 28, Beijing, Peoples R China

[2] Capital Med Univ, Beijing Shijitan Hosp, Dept Special Med Treatment Resp Dis, 10 Tieyi Rd, Beijing 100038, Peoples R China

[3] Capital Med Univ, Beijing Shijitan Hosp, Peking Univ, Sch Clin Med 9, Beijing, Peoples R China

[4] PLA Rocket Force, Gen Hosp, Dept Resp Dis, Beijing, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 06期

关键词：

Lung cancer; transforming growth factor beta; signaling pathway; Smad; SUPERFAMILY SIGNALING PATHWAYS; TUMOR-SUPPRESSOR SMAD4; II RECEPTOR GENE; TGF-BETA; TGF-BETA-1; GENE; GROWTH-FACTOR-BETA-1; LEVEL; MESENCHYMAL TRANSITION; DEFECTIVE EXPRESSION; CELL-MEMBRANE; ADENOCARCINOMA;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

As the No. 1 killing cancer in the world, the incidence of lung cancer is still on the rise across the globe these years, such a trend is particularly apparent in China. To study the molecular mechanism of the occurrence of lung cancer and develop new anti-cancer drugs is an arduous task confronting medical researchers of the whole world. Multiple signaling pathways are involved in the lung carcinogenesis. Transforming Growth Factor-beta family (TGF-beta), known as a multi-functional cytokine superfamily, plays extensively regulatory roles in life activities, including morphogenesis, embryonic development, immunoregulation, healing of wound, as well as inflammation and tumor. Here we review the roles of TGF-beta signal transduction pathway in lung cancer.

引用

页码：9766 / 9780

页数：15

共 153 条

[1] Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6 [J].

Abulaiti, Abulimiti ;

Shintani, Yasushi ;

Funaki, Soichiro ;

Nakagiri, Tomoyuki ;

Inoue, Masayohi ;

Sawabata, Noriyoshi ;

Minami, Masato ;

Okumura, Meinoshin .

LUNG CANCER, 2013, 82 (02) :204-213

[2]

Akhurst RJ, 2001, TRENDS CELL BIOL, V11, pS44, DOI 10.1016/S0962-8924(01)82259-5

[3]

ANDRES JL, 1991, J BIOL CHEM, V266, P23282

[4] Making sense of latent TGFβ activation [J].

Annes, JP ;

Munger, JS ;

Rifkin, DB .

JOURNAL OF CELL SCIENCE, 2003, 116 (02) :217-224

[5]

[Anonymous], 2018, ANTI-CANCER DRUG, DOI [DOI 10.3322/caac.20115, DOI 10.1097/CAD.0000000000000617]

[6] Restoration of TGF-β signalling reduces tumorigenicity in human lung cancer cells [J].

Anumanthan, G ;

Halder, SK ;

Osada, H ;

Takahashi, T ;

Massion, PP ;

Carbone, DP ;

Datta, PK .

BRITISH JOURNAL OF CANCER, 2005, 93 (10) :1157-1167

[7] SARCOMA GROWTH-FACTOR FROM CONDITIONED MEDIUM OF VIRALLY TRANSFORMED-CELLS IS COMPOSED OF BOTH TYPE-ALPHA AND TYPE-BETA TRANSFORMING GROWTH-FACTORS [J].

ANZANO, MA ;

ROBERTS, AB ;

SMITH, JM ;

SPORN, MB ;

DELARCO, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (20) :6264-6268

[8] Inhibition of TGFβ signaling in cancer therapy [J].

Arteaga, CL .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (01) :30-37

[9] Signal transduction by the TGF-β superfamily [J].

Attisano, L ;

Wrana, JL .

SCIENCE, 2002, 296 (5573) :1646-1647

[10] TGF-BETA RECEPTORS AND ACTIONS [J].

ATTISANO, L ;

WRANA, JL ;

LOPEZCASILLAS, F ;

MASSAGUE, J .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1994, 1222 (01) :71-80

← 1 2 3 4 5 6 7 8 9 10 →