Development and Evaluation of Antipyretic and Antinociceptive Activity of Polyherbal Formulation Containing Some Indigenous Medicinal Plants

In the present study, it was envisaged to prepare three polyherbal formulations (F-1, F-2 and F-3) containing leaves of Solanum xanthocarpum and Andrographis paniculata, rhizomes of Curcuma longa and stem of Tinospora cordifolia in varying ratio and evaluating the polyherbal formulations for the antipyretic and antinociceptive activities. The antipyretic activity of methanol extracts (MF1, MF2 and MF3) and aqueous extracts (AF(1), AF(2) and AF(3)) of polyherbal formulation were studied in Brewer's yeast induced pyrexia in mice. The antinociceptive activity of methanol and aqueous extracts of polyherbal formulation were studied using Eddy's hot plate method and tail flick method in mice. The polyherbal formulation of all extracts showed significant reduction in the elevated body temperature of rat which was compared with standard paracetamol. The extract of polyherbal formulation produced significant increase in the reaction time by Eddy's hot plate method and tail flick method in mice which was compared with standard morphine sulphate. From these results it may be concluded that AF(1) formulation demonstrated maximum significant antipyretic and antinociceptive activities that might be due to combined effect of active constituents present in all plant material.