Utilization of mouse models in the discovery of human disease genes

被引：20

作者：

Moore, KJ ^{[1
]}

机构：

[1] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

DRUG DISCOVERY TODAY | 1999年 / 4卷 / 03期

关键词：

D O I：

10.1016/S1359-6446(99)01304-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mouse is a powerful model organism for studying human disease. By the use of various breeding strategies in combination with positional cloning and positional candidates, many genes underlying human disease have been and will continue to be discovered through the use of mouse genetics. The author illustrates how the mouse can be used to discover human disease genes underlying simple mendelian and complex polygenic diseases and genes involved in the modification of disease.

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收藏

页码：123 / 128

页数：6

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