Inflammation and Stroke: An Overview

被引：753

作者：

Anrather, Josef ^{[1
]}

Iadecola, Costantino ^{[1
]}

机构：

[1] Weill Cornell Med, Feil Family Brain & Mind Res Inst, New York, NY 10065 USA

来源：

NEUROTHERAPEUTICS | 2016年 / 13卷 / 04期

关键词：

Stroke; ischemia; inflammation; immune response; immunomodulation; FOCAL CEREBRAL-ISCHEMIA; REGULATORY T-CELLS; MURINE EXPERIMENTAL STROKE; BRAIN-BARRIER BREAKDOWN; NITRIC-OXIDE SYNTHASE; IMMUNE-SYSTEM; MONONUCLEAR-CELLS; INTERFERON-GAMMA; GUT MICROBIOTA; INFARCT SIZE;

D O I：

10.1007/s13311-016-0483-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The immune response to acute cerebral ischemia is a major factor in stroke pathobiology and outcome. While the immune response starts locally in occluded and hypoperfused vessels and the ischemic brain parenchyma, inflammatory mediators generated in situ propagate through the organism as a whole. This "spillover" leads to a systemic inflammatory response first, followed by immunosuppression aimed at dampening the potentially harmful proinflammatory milieu. In this overview we will outline the inflammatory cascade from its starting point in the vasculature of the ischemic brain to the systemic immune response elicited by brain ischemia. Potential immunomodulatory therapeutic approaches, including preconditioning and immune cell therapy will also be discussed.

引用

页码：661 / 670

页数：10

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