Exosomes: key players in cancer and potential therapeutic strategy

被引：885

作者：

Dai, Jie ^{[1
,2
]}

Su, Yangzhou ^{[1
,2
]}

Zhong, Suye ^{[1
,2
]}

Cong, Li ^{[1
,2
]}

Liu, Bang ^{[1
,2
]}

Yang, Junjun ^{[3
]}

Tao, Yongguang ^{[4
]}

He, Zuping ^{[1
,2
]}

Chen, Chao ^{[5
]}

Jiang, Yiqun ^{[1
,2
]}

机构：

[1] Hunan Normal Univ, Key Lab Model Anim & Stem Cell Biol Hunan Prov, Changsha 410013, Hunan, Peoples R China

[2] Hunan Normal Univ, Sch Med, Changsha 410013, Hunan, Peoples R China

[3] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Ctr Joint Surg, Chongqing 400038, Peoples R China

[4] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Dept Pathol,Xiangya Hosp,Sch Basic Med, Changsha 410078, Hunan, Peoples R China

[5] Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Nanjing 210013, Jiangsu, Peoples R China

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2020年 / 5卷 / 01期

基金：

中国国家自然科学基金;

关键词：

CELL-DERIVED EXOSOMES; LONG NONCODING RNAS; MULTIPLE-MYELOMA; DENDRITIC CELLS; STEM-CELLS; T-CELL; EXTRACELLULAR VESICLES; MEDIATED METASTASIS; CIRCULAR RNA; PROGRESSION;

D O I：

10.1038/s41392-020-00261-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long noncoding RNA, circular RNA, etc., which play a crucial role in regulating tumor growth, metastasis, and angiogenesis in the process of cancer development, and can be used as a prognostic marker and/or grading basis for tumor patients. Hereby, we mainly summarized as followed: the role of exosome contents in cancer, focusing on proteins and noncoding RNA; the interaction between exosomes and tumor microenvironment; the mechanisms that epithelial-mesenchymal transition, invasion and migration of tumor affected by exosomes; and tumor suppression strategies based on exosomes. Finally, the application potential of exosomes in clinical tumor diagnosis and therapy is prospected, which providing theoretical supports for using exosomes to serve precise tumor treatment in the clinic.

引用

页数：10

共 165 条

[1] Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes [J].