A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application

被引：207

作者：

Garland, Megan ^{[1
,2
]}

Yim, Joshua J. ^{[3
]}

Bogyo, Matthew ^{[1
,2
,3
,4
]}

机构：

[1] Stanford Univ, Canc Biol Program, Sch Med, 300 Pasteur Dr, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Pathol, 300 Pasteur Dr, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Chem & Syst Biol, 300 Pasteur Dr, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Dept Microbiol & Immunol, 300 Pasteur Dr, Stanford, CA 94305 USA

来源：

CELL CHEMICAL BIOLOGY | 2016年 / 23卷 / 01期

基金：

美国国家科学基金会;

关键词：

NEAR-INFRARED FLUORESCENCE; CELL-PENETRATING PEPTIDES; CARBOXYPEPTIDASE-II NAALADASE; CYSTEINE PROTEASE ACTIVITY; IN-VIVO; PROSTATE-CANCER; MEMBRANE ANTIGEN; IMAGING AGENTS; INTRAOPERATIVE VISUALIZATION; INDOCYANINE GREEN;

D O I：

10.1016/j.chembiol.2015.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Precision Medicine Initiative aims to use advances in basic and clinical research to develop therapeutics that selectively target and kill cancer cells. Under the same doctrine of precision medicine, there is an equally important need to visualize these diseased cells to enable diagnosis, facilitate surgical resection, and monitor therapeutic response. Therefore, there is a great opportunity for chemists to develop chemically tractable probes that can image cancer in vivo. This review focuses on recent advances in the development of optical probes, as well as their current and future applications in the clinical management of cancer. The progress in probe development described here suggests that optical imaging is an important and rapidly developing field of study that encourages continued collaboration among chemists, biologists, and clinicians to further refine these tools for interventional surgical imaging, as well as for diagnostic and therapeutic applications.

引用

页码：122 / 136

页数：15

共 108 条

[1] Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy [J].