Application of temperature gradient gel electrophoresis method for studying the sheep prion protein (PrP) gene polymorphism

被引：0
|
作者：
Jasik, A [1 ]
Reichert, M [1 ]
机构：
[1] Natl Inst Vet Res, Dept Pathol, PL-24100 Pulawy, Poland
来源：
BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY | 2003年 / 47卷 / 02期
关键词：
sheep; scrapie; prion protein; polymorphism; TGGE;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
This study presents the preliminary data on the polymorphism of the PrP gene using two breeds of sheep occurring in Poland, i.e. Wrzosowka and Swiniarka. Available data indicate that presence of allele encoding valine at codon 136 in many breeds of sheep is associated with high sensitivity to scrapie. Our study did not reveal presence of this allele in the examined sheep. The highest variability was observed in codon 171:RR171 associated with resistance to scrapie and in codon QQ(171), correlated with sensitivity to the disease.
引用
收藏
页码：341 / 348
页数：8
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