Insulin-like growth factor-I in muscle metabolism and myotherapies

被引:51
作者
Singleton, JR
Feldman, EL
机构
[1] Univ Utah, Dept Neurol, Salt Lake City, UT 84108 USA
[2] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
关键词
D O I
10.1006/nbdi.2001.0416
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The critical anabolic and trophic role of signaling by insulin-like growth factors (IGF) I and II via the type-I IGF receptor (IGF-IR) is reviewed throughout the life of skeletal myocytes. The proliferative effects of IGF-IR stimulation, both during embryogenesis and during satellite cell proliferation following denervation or muscle injury, are mediated primarily through activation of mitogen-activated protein kinases. Signaling through phosphatidylinositol 3-kinase is essential to muscle protein synthesis and glucose uptake and may contribute to the observed resilience of mature muscle to programmed cell death. Degeneration or inhibition of the GH-IGF-I axis by aging, cachexia, sepsis, diabetes, drugs, and disuse all enhance muscle catabolism, and opposition of these effects by IGF-I may form the basis of effective myotherapy. (C) 2001 Academic Press.
引用
收藏
页码:541 / 554
页数:14
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