Avibactam Restores the Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia to Aztreonam

被引：51
|
作者：
Mojica, Maria F. [1 ,2 ]
Papp-Wallace, Krisztina M. [1 ,2 ,3 ]
Taracila, Magdalena A. [2 ,3 ]
Barnes, Melissa D. [2 ,3 ]
Rutter, Joseph D. [2 ]
Jacobs, Michael R. [4 ,5 ]
LiPuma, John J. [6 ]
Walsh, Thomas J. [7 ]
Villa, Alejandro J. [8 ,9 ]
Bonomo, Robert A. [1 ,3 ,10 ,11 ,12 ,13 ,14 ,15 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA
[2] Louis Stokes Vet Affairs Med Ctr, Res Serv, Cleveland, OH USA
[3] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA
[4] Univ Hosp Cleveland, Med Ctr, Dept Pathol, Cleveland, OH 44106 USA
[5] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA
[6] Univ Michigan, Med Sch, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA
[7] Weill Cornell Med Ctr, Transplantat Oncol Infect Dis Program, New York, NY USA
[8] UNR, CONICET, Inst Biol Mol & Celular Rosario IBR, Rosario, Argentina
[9] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, Area Biofis, Rosario, Argentina
[10] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA
[11] Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA
[12] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA
[13] Case Western Reserve Univ, Sch Med, Dept Prote & Bioinformat, Cleveland, OH 44106 USA
[14] Louis Stokes Cleveland, Dept Vet Affairs Med Ctr, Med Serv & GRECC, Cleveland, OH USA
[15] CWRU Cleveland, VAMC Ctr Antimicrobial Resistance & Epidemiol Cas, Cleveland, OH USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 10期
基金：
美国国家卫生研究院;
关键词：
aztreonam; S; maltophilia; avibactam; BETA-LACTAMASES; CYSTIC-FIBROSIS; INHIBITION;
D O I：
10.1128/AAC.00777-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 beta-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.
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页数：5
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