The use of hypoxene in the treatment of patients with chronic heart failure

This study aimed to compare the effect of treatment with hypoxene and standard medical treatment for the oxidative stress (catalase (CAT), lipid peroxidation (LPO), inhibition of superoxide dismutase (SOD), diene conjugates (DC) and malondialdehyde (MDA) at the admission and at the end of treatment in hospital, after 6 months, 1 year in patients with CFH. This prospective study included 158 patients with CHS who were treated at the State Budgetary Institutions "Clinical Hospital N degrees 1 of Grozny" and "Clinical Hospital No 5 of Grozny" in 2017. All the patients divided into two groups. Group A treat hypoxen and standard medical therapy, and Group B - non-treat hypoxene and standard medical therapy, as a control group. The patients of group A were then given 750 mg/d hypoxene for 4 weeks. Blood samples were collected from the patients on admission and at the end of the study, after 6 months, 1 year. Mean age of group A patients were 49 +/- 6.3 years while in control group it was 51 +/- 9.4 years. There were 48 males in group A patients and 43 males in control subjects. The levels of LPO were found to be significantly increased in group A patients compared to control (P< 0.05). The catalase, MDA, DC and SOD levels were significantly decreased (P< 0.05) in group A patients compared to controls. During the treatment of patients of the studied groups showed a significant decline in lipid peroxidation.