3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier

被引：19

作者：

Baik, Hye Jung ^{[1
]}

Oh, Nam Muk ^{[1
]}

Oh, Young Taik ^{[2
]}

Yoo, Na Young ^{[1
]}

Park, So Young ^{[1
]}

Oh, Kyung Taek ^{[3
]}

Youn, Yu Seok ^{[4
]}

Lee, Eun Seong ^{[1
]}

机构：

[1] Catholic Univ Korea, Div Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea

[2] Yonsei Univ, Coll Med, Dept Diagnost Radiol, Seoul 120752, South Korea

[3] Chung Ang Univ, Coll Pharm, Seoul 155756, South Korea

[4] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2011年 / 84卷 / 02期

关键词：

Polysaccharidic nanogels; Glycol chitosan; Bovine serum albumin; Ph-sensitivity; DELIVERY; NANOPARTICLES; NANOGELS; CELLS;

D O I：

10.1016/j.colsurfb.2011.01.017

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Polysaccharidic nanogels were fabricated with bovine serum albumin (BSA) and a glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups. These nanogels were investigated to evaulate their cellular uptake in HeLa cells and in vivo fate in nude mice tumor model. Unlike free BSA, GCS-g-DEAP/BSA nanogels improved cellular uptake of BSA. Furthermore, this system led to an enhanced blood circulation and a high accumulation of BSA in the tumor site. Our collective results strongly support that GCS-g-DEAP/BSA nanogel is a potential carrier system for high molecular weight proteins. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：585 / 590

页数：6

共 18 条

[1] Chlorin e6-polyvinylpyrrolidone as a fluorescent marker for fluorescence diagnosis of human bladder cancer implanted on the chick chorioallantoic membrane model [J].

Chin, William Wei Lim ;

Lau, Weber Kam On ;

Bhuvaneswari, Ramaswamy ;

Heng, Paul Wan Sia ;

Olivo, Malini .

CANCER LETTERS, 2007, 245 (1-2) :127-133

[2] Protein function in the post-genomic era [J].

Eisenberg, D ;

Marcotte, EM ;

Xenarios, I ;

Yeates, TO .

NATURE, 2000, 405 (6788) :823-826

[3] Anticancer Activity and Molecular Mechanism of Resveratrol-Bovine Serum Albumin Nanoparticles on Subcutaneously Implanted Human Primary Ovarian Carcinoma Cells in Nude Mice [J].

Guo, Liyuan ;

Peng, Yan ;

Yao, Jingping ;

Sui, Lihua ;

Gu, Anxin ;

Wang, Jing .

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2010, 25 (04) :471-477

[4] Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities [J].

Kabanov, Alexander V. ;

Vinogradov, Serguei V. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (30) :5418-5429

[5] Synthesis and Evaluation of Human Serum Albumin-Modified Exendin-4 Conjugate via Heterobifunctional Polyethylene Glycol Linkage with Protracted Hypoglycemic Efficacy [J].

Kim, Insoo ;

Kim, Tae Hyung ;

Ma, Kyungwan ;

Lee, Eun Seong ;

Kim, Dongin ;

Oh, Kyung Taek ;

Lee, Don Haeng ;

Lee, Kang Choon ;

Youn, Yu Seok .

BIOCONJUGATE CHEMISTRY, 2010, 21 (08) :1513-1519

[6] Ionic complex systems based on hyaluronic acid and PEGylated TNF-related apoptosis-inducing ligand for treatment of rheumatoid arthritis [J].

Kim, Yu-Jeong ;

Chae, Su Young ;

Jin, Cheng-Hao ;

Sivasubramanian, M. ;

Son, Sohee ;

Choi, Ki Young ;

Jo, Dong-Gyu ;

Kim, Kwangmeyung ;

Kwon, Ick Chan ;

Lee, Kang Choon ;

Park, Jae Hyung .

BIOMATERIALS, 2010, 31 (34) :9057-9064

[7] A charge-switched nano-sized polymeric carrier for protein delivery [J].

Lee, Bo Reum ;

Oh, Kyung Taek ;

Baik, Hye Jung ;

Youn, Yu Seok ;

Lee, Eun Seong .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 392 (1-2) :78-82

[8] Protein complexed with chondroitin sulfate in poly(lactide-co-glycolide) microspheres [J].

Lee, Eun Seong ;

Park, Keun-Hong ;

Kang, Dongmin ;

Park, In Suh ;

Min, Hyo Young ;

Lee, Don Haeng ;

Kim, Sungwon ;

Kim, Jong Ho ;

Na, Kun .

BIOMATERIALS, 2007, 28 (17) :2754-2762

[9] Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects [J].

Maeda, Hiroshi .

BIOCONJUGATE CHEMISTRY, 2010, 21 (05) :797-802

[10] The Reversal of Drug-Resistance in Tumors Using a Drug-Carrying Nanoparticular System [J].

Oh, Kyung Taek ;

Baik, Hye Jung ;

Lee, A. Hyeong ;

Oh, Young Taik ;

Youn, Yu Seok ;

Lee, Eun Seong .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2009, 10 (09) :3776-3792

← 1 2 →