Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase

被引：26

作者：

Samala, Niharika ^{[1
,2
]}

Tersey, Sarah A. ^{[2
,3
]}

Chalasani, Naga ^{[1
,2
,4
]}

Anderson, Ryan M. ^{[2
,3
,4
]}

Mirmira, Raghavendra G. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Ctr Diabet & Metab Dis, Indianapolis, IN 46202 USA

[3] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA

[4] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA

[5] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2017年 / 31卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Non-alcoholic fatty liver disease; Fatty liver; Lipoxygenase; Oxidative stress; Obesity; VITAMIN-E; LIPID-PEROXIDATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; WEIGHT-LOSS; SELECTIVE INHIBITORS; METABOLIC SYNDROME; HEPATIC STEATOSIS; BARIATRIC SURGERY; CONTROLLED-TRIAL;

D O I：

10.1016/j.jdiacomp.2017.07.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population. It is commonly associated with features of metabolic syndrome, particularly insulin resistance. NAFLD shares the basic pathogenic mechanisms with obesity and insulin resistance, such as mitochondrial, oxidative and endoplasmic reticulum stress. Lipoxygenases catalyze the conversion of poly-unsaturated fatty acids in the plasma membrane mainly arachidonic acid and linoleic acid-to produce oxidized pro-inflammatory lipid intermediates. 12-Lipoxygenase (12-LOX) has been studied extensively in setting of inflammation and insulin resistance. As insulin resistance is closely associated with development of NAFLD, the role of 12-LOX in pathogenesis of NAFLD has received increasing attention in recent years. In this review we discuss the role of 12-LOX in NAFLD pathogenesis and its potential role in emerging new therapeutics. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：1630 / 1637

页数：8

共 107 条

[1] Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis [J].