Design and Stability Improvement of Pectin-Based Red Blood Cell-Mimicking Microcapsules for Oxygen Therapeutics

被引：1

作者：

Phakousonh, Damien ^{[1
]}

Wang, Yale ^{[2
]}

Schlicht, Sabrina ^{[1
]}

Wiskirchen, Sam ^{[1
]}

Bos, Trevor ^{[1
]}

Ren, Lixia ^{[3
]}

Chen, Junhong ^{[2
,4
,5
]}

Hua, Xiaolin ^{[6
]}

Lee, Jung ^{[1
]}

Krishnan, Sasirekha ^{[7
]}

Suresh, K. Shoma ^{[7
]}

Jaisankar, Abinaya ^{[7
]}

Ramalingam, Murugan ^{[7
]}

Zhang, Wujie ^{[1
]}

机构：

[1] Milwaukee Sch Engn, Phys & Chem Dept, BioMol Engn Program, Milwaukee, WI 53202 USA

[2] Univ Wisconsin, Dept Mech Engn, Milwaukee, WI 53211 USA

[3] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China

[4] Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL 60637 USA

[5] Argonne Natl Lab, Phys Sci & Engn Directorate, Lemont, IL 60439 USA

[6] Tongji Univ, Shanghai Matern & Infant Hosp 1, Dept Obstet, Sch Med, Shanghai 201204, Peoples R China

[7] Vellore Inst Technol, Sch Mech Engn, Biomat & Organ Engn Grp, Ctr Biomat Cellular & Mol Theranost, Vellore 632014, Tamil Nadu, India

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2021年 / 17卷 / 09期

关键词：

Microcapsules; Oxygen Therapeutics; Pectin; Oligochitosan; Hydrogel; BOVINE HEMOGLOBIN; GLUTARALDEHYDE; ALGINATE;

D O I：

10.1166/jbn.2021.3154

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A pectin-oligochitosan microcapsule system has recently been developed for novel oxygen therapeutic design. To improve IP: 49.249.253.194 On: Mon, 25 Oct 2021 08:53:20 Copyight Ame ic n S ie tifi Publi he s the stability of the pectin-oligochitosan microcapsules in physiological conditions, both covalent (glutaraldehyde) and non De ivered by Ingenta covalent (Mn2+ and Ca2+) cross-linkers were tested. The chemistry and morphology of the microcapsules were studied using FTIR and SEM, respectively. Results showed that glutaraldehyde is an effective cross-linker, even at low concentrations and short incubation times, and the glutaraldehyde cross-linking does not negatively impact the morphology of the microcapsules. Moreover, it was confirmed that the hemoglobin could be retained within the microcapsules with a minimal release.

引用

页码：1798 / 1805

页数：8

共 6 条

[1] Stability improvement and characterization of bioprinted pectin-based scaffold
Stealey, Samuel
Guo, Xiaoru
Ren, Lixia
Bryant, Elizabeth
Kaltchev, Matey
Chen, Junhong
Kumpaty, Subha
Hua, Xiaolin
Zhang, Wujie
JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, 2019, 17 (01)
[2] Design of a Novel Oxygen Therapeutic Using Polymeric Hydrogel Microcapsules Mimicking Red Blood Cells
Cherwin, Amanda
Namen, Shelby
Rapacz, Justyna
Kusik, Grace
Anderson, Alexa
Wang, Yale
Kaltchev, Matey
Schroeder, Rebecca
O'Connell, Kellen
Stephens, Sydney
Chen, Junhong
Zhang, Wujie
PHARMACEUTICS, 2019, 11 (11)
[3] Design of artificial red blood cells using polymeric hydrogel microcapsules: hydrogel stability improvement and polymer selection
Zhang, Wujie
Bissen, Matthew J.
Savela, Emily S.
Clausen, Joshua N.
Fredricks, Samantha J.
Guo, Xiaoru
Paquin, Zachary R.
Dohn, Ryan P.
Pavelich, Ian J.
Polovchak, Alec L.
Wedemeyer, Michael J.
Shilling, Brock E.
Dufner, Emily N.
O'Donnell, Anna C.
Rubio, Gerardo
Readnour, Logan R.
Brown, Tyler F.
Lee, Jung C.
Kaltchev, Matey G.
Chen, Junhong
Tritt, Charles S.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2016, 39 (10) : 518 - 523
[4] Facile construction of pectin-based hesperidin microcapsules: Solubilization, stability, loading process, and release mechanism
Zhou, Peng
Li, Xiangzhou
Jiang, Zhi
Zhou, Jun
Shen, Liqun
FOOD CHEMISTRY, 2024, 451
[5] Internalization of Red Blood Cell-Mimicking Hydrogel Capsules with pH-Triggered Shape Responses
Kozlovskaya, Veronika
Alexander, Jenolyn F.
Wang, Yun
Kuncewicz, Thomas
Liu, Xuewu
Godin, Biana
Khariampieva, Eugenia
ACS NANO, 2014, 8 (06) : 5725 - 5737
[6] A Safety and Efficacy Evaluation of Hemoglobin-Based Oxygen Carrier HBOC-201 in a Randomized, Multicenter Red Blood Cell Controlled Trial in Noncardiac Surgery Patients
Van Hemelrijck, Jan
Levien, Lewis J.
Veeckman, Luc
Pitman, Arkadiy
Zafirelis, Zafiris
Standl, Thomas
ANESTHESIA AND ANALGESIA, 2014, 119 (04) : 766 - 776

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