Glomerular haematuria, renal interstitial haemorrhage and acute kidney injury

被引：40

作者：

Martin Cleary, Catalina ^{[1
]}

Antonio Moreno, Juan ^{[1
]}

Fernandez, Beatriz ^{[1
]}

Ortiz, Alberto ^{[1
,2
,3
]}

Parra, Emilio G. ^{[1
]}

Gracia, Carolina ^{[1
]}

Blanco-Colio, Luis M. ^{[1
]}

Barat, Antonio ^{[4
]}

Egido, Jesus ^{[1
,2
,3
]}

机构：

[1] IIS Fdn Jimenez Diaz, Dept Nephrol, Madrid, Spain

[2] Univ Autonoma Madrid, Madrid, Spain

[3] Fdn Renal Inigo Alvarez Toledo, Madrid, Spain

[4] Fdn Jimenez Diaz, Dept Pathol, E-28040 Madrid, Spain

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2010年 / 25卷 / 12期

关键词：

acute renal failure; haematuria; IgA nephropathy; interstitial haemorrhage; HEMOGLOBIN SCAVENGER RECEPTOR; IGA NEPHROPATHY; MACROSCOPIC HEMATURIA;

D O I：

10.1093/ndt/gfq493

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Macroscopic haematuria of glomerular origin has been associated with acute kidney injury. We report a patient with IgA nephropathy, macroscopic haematuria and acute kidney injury. Systemic anticoagulation may have aggravated haematuria. There was extensive interstitial and intratubular red blood cell extravasation, and interstitial haemosiderin deposits. The abundant presence of macrophages expressing the haemoglobin scavenger receptor CD163 and of cells stained for oxidative stress markers (NADPH-p22 phox and heme-oxigenase-1) in areas of interstitial haemorrhage and red blood cell cast-containing tubules provided evidence for a role for free haemoglobin in tubulointerstitial renal injury in human glomerular disease.

引用

页码：4103 / 4106

页数：4

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