Supported synthesis and functionnalization of 2′-deoxyuridine by Suzuki-Miyaura cross-coupling

被引：6

作者：

El Kazzouli, Said ^{[1
]}

Berteina-Raboin, Sabine ^{[1
]}

Agrofoglio, Luigi A. ^{[1
]}

机构：

[1] Univ Orleans, Inst Chim Organ & Analyt, CNRS, UMR 6005, F-45067 Orleans 2, France

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 10-12期

关键词：

polystyrene; solid phase; Pd(0) cross-coupling; Suzuki-Miyaura; nucleosides;

D O I：

10.1080/15257770701534170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and modification of 2-deoxyuridine has been realized under Suzuki-Miyaura palladium-catalyzed cross-coupling conditions. Using Pd(PPh3)(4) and Na2CO3, 5-iodo-2'deoxyuridine bound to solid support is coupled with various boronic acids to give 5-(hetero)aryl-2'-deoxyuridine. Pd(PPh3)(4) palladium catalyzed was found to be superior to Pd(OAc)(2) and (NHC)Pd(allyl)Cl for Suzuki-Miyaura palladium-catalyzed reactions.

引用

页码：1395 / 1398

页数：4

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