Lupane-type triterpenoids from the steamed leaves of Acanthopanax koreanum and their inhibitory effects on the LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells

被引：29

作者：

Kim, Jeong Ah ^{[1
]}

Yang, Seo Young ^{[1
]}

Koo, Jung-Eun ^{[2
,3
]}

Koh, Young-Sang ^{[2
,3
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Cheju Natl Univ, Sch Med, Cheju 690756, South Korea

[3] Cheju Natl Univ, Brain Korea Program 21, Cheju 690756, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 22期

关键词：

Acanthopanax koreanum; Lupane-type triterpenoids; Bone marrow-derived dendritic cells; IL-12; IL-6; TNF-alpha; IMMUNE-RESPONSES; GLYCOSIDES; TRANSCRIPTION; DITERPENOIDS; MURINE; ACID; ROOT;

D O I：

10.1016/j.bmcl.2010.09.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new compounds, (20R)-3 alpha-hydroxy-29-dimethoxylupan-23,28-dioic acid (1) and 3a-hydroxylup-20(29)-ene-23,28-dioic acid 28-O-[beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl] ester (2), and eight known lupane-type triterpenoids (3-10), were isolated from steamed leaves of Acanthopanax koreanum. Chemical structures were determined using a combination of spectroscopic analyses and chemical reactivity. Compounds 1-10 were evaluated for their inhibitory activities on lipopolysaccharide (LPS)-stimulated interleukin (IL)-12 production in bone marrow-derived dendritic cells (BMDCs). Compound 1 exhibited inhibitory activity with IC(50) value of 26.5 mu M on IL-12 production, compared with IC(50) value of 29.6 mu M for the positive control. Compound 1 also showed significant suppression of LPS-stimulated IL-6 and tumor necrosis factor-alpha (TNF-alpha) production. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6703 / 6707

页数：5

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