Suspensory ligament degeneration associated with pituitary pars intermedia dysfunction in horses

被引：19

作者：

Hofberger, Sina ^{[1
]}

Gauff, Felicia ^{[1
]}

Licka, Theresia ^{[1
,2
]}

机构：

[1] Univ Vet Med Vienna Vetmeduni Vienna, Equine Clin, A-1210 Vienna, Austria

[2] Royal Dick Sch Vet Studies, Large Anim Hosp, Edinburgh EH25 9RG, Midlothian, Scotland

来源：

VETERINARY JOURNAL | 2015年 / 203卷 / 03期

关键词：

Equine; Pituitary pars intermedia dysfunction; Suspensory ligament; Cortisol;

D O I：

10.1016/j.tvjl.2014.12.037

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In older horses, pituitary pars intermedia dysfunction (PPID) and suspensory ligament (SL) degeneration are common. The aim of the present study was to identify histopathological changes in the SL in horses with PPID. SLs of four horses with clinical signs of PPID (17-26 years of age) were compared with SLs from four old horses (18-31 years of age) and three young horses (4-9 years of age). In horses with PPID, there was reduced longitudinal arrangement of collagen fibres in SLs, along with inclusions of cartilage, extracellular matrix and haemorrhage, as well as significant proteoglycan accumulations between SL fibres. These changes are similar to the degeneration of connective tissues in Peruvian Paso horses with SL degeneration and in humans with Cushing's disease or after long term high dose corticosteroid treatments. These findings indicate an association between degeneration of the SL and PPID. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：348 / 350

页数：3

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