Regular exercise reduces colon tumorigenesis associated with suppression of iNOS

被引：45

作者：

Aoi, Wataru ^{[1
,2
]}

Naito, Yuji ^{[2
]}

Takagi, Tomohisa ^{[2
]}

Kokura, Satoshi ^{[2
]}

Mizushima, Katsura ^{[2
]}

Takanami, Yoshikazu ^{[3
]}

Kawai, Yukari ^{[4
]}

Tanimura, Yuko ^{[2
]}

Hung, Liu Po ^{[2
]}

Koyama, Ryota ^{[2
]}

Ichikawa, Hiroshi ^{[5
]}

Yoshikawa, Toshikazu ^{[2
]}

机构：

[1] Kyoto Prefectural Univ, Grad Sch Life & Environm Sci, Lab Hlth Sci, Kyoto 6068522, Japan

[2] Kyoto Prefectural Univ Med, Dept Gastroenterol & Hepatol, Kyoto, Japan

[3] Otsuma Womens Univ, Dept Home Econ, Tokyo, Japan

[4] Louis Pasteur Ctr Med Res, Kyoto, Japan

[5] Doshisha Univ, Dept Med Life Syst, Kyoto 602, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 399卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

Tumorigenesis; Azoxymethan; iNOS; Anti-inflammation; Running exercise; NITRIC-OXIDE SYNTHASE; ABERRANT CRYPT FOCI; MALE F344 RATS; PHYSICAL-ACTIVITY; TNF-ALPHA; KAPPA-B; EXPRESSION; CANCER; CELLS; RISK;

D O I：

10.1016/j.bbrc.2010.07.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several epidemiological studies have shown that regular exercise can prevent the onset of colon cancer, although the mechanism involved is unclear. Expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) is often elevated in an initial step of tumorigenesis and promotes colorectal cancer. We investigated the effect of exercise on colon tumorigenesis associated with iNOS and COX-2 in azoxymethan (AOM)-injected mice. Balb/c mice (8 weeks old) were divided into three groups of 20 animals each, consisting of a sedentary control group, an AOM group, and an exercise plus AOM group. Mice in the groups receiving AOM were injected intraperitoneally with AOM weekly for 2 weeks. Six weeks of regular exercise suppressed the generation of aberrant crypt foci (ACF) in the colon by AOM. Expression of iNOS was decreased by exercise compared with that in sedentary mice along with lower nitrotyrosine level while COX-2 was not changed by either AOM or exercise. Additionally, tumor necrosis factor a (TNF alpha) was decreased by exercise in the colon and plasma. There was no effect of exercise on the expression of antioxidant enzymes and chaperon protein in the colon. Our results suggest that regular exercise prevents colon tumorigenesis, at least partly via the suppression of iNOS expression associated with anti-inflammation. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：14 / 19

页数：6

共 35 条

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