Clinical Impact of Pretreatment Human Immunodeficiency Virus Drug Resistance in People Initiating Nonnucleoside Reverse Transcriptase Inhibitor-Containing Antiretroviral Therapy: A Systematic Review and Meta-analysis

被引：51

作者：

Bertagnolio, Silvia ^{[1
]}

Hermans, Lucas ^{[2
,3
]}

Jordan, Michael R. ^{[4
,5
,6
]}

Avila-Rios, Santiago ^{[7
]}

Iwuji, Collins ^{[8
]}

Derache, Anne ^{[9
]}

Delaporte, Eric ^{[10
]}

Wensing, Annemarie ^{[2
,3
]}

Aves, Theresa ^{[11
]}

Borhan, A. S. M. ^{[11
]}

Leenus, Alvin ^{[11
]}

Parkin, Neil ^{[12
]}

Doherty, Meg ^{[1
]}

Inzaule, Seth ^{[1
]}

Mbuagbaw, Lawrence ^{[11
]}

机构：

[1] WHO, Global HIV Hepatitis & STI Programmes, 20 Ave Appia, CH-1211 Geneva, Switzerland

[2] Univ Med Ctr Utrecht, Dept Med Microbiol, Virol, Utrecht, Netherlands

[3] Univ Witwatersrand, Wits Reprod Hlth & HIV Inst, Johannesburg, South Africa

[4] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA

[5] Tufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA

[6] Tufts Ctr Integrated Management Antimicrobial Res, Boston, MA USA

[7] Inst Nacl Enfermedades Resp, Ctr Invest Enfermedades Infecciosas, Mexico City, DF, Mexico

[8] Univ Sussex, Brighton & Sussex Med Sch, Dept Global Hlth & Infect, Falmer, England

[9] Africa Hlth Res Inst, Kwa Zulu, South Africa

[10] Univ Montpellier, Inst Rech Dev, Inst Natl Sante & Rech Med, TransVIHMI, Montpellier, France

[11] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[12] Data First Consulting, Sebastopol, CA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 224卷 / 03期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

pretreatment HIV drug resistance; HIV drug resistance; virological failure; treatment failure; ART; NNRTIs; HIV-INFECTED CHILDREN; VIROLOGICAL FAILURE; PREVALENCE; COMBINATION; GENOTYPE; OUTCOMES; REGIMEN; WOMEN;

D O I：

10.1093/infdis/jiaa683

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Increased access to antiretroviral therapy (ART) has resulted in rising levels of pretreatment human immunodeficiency virus drug resistance (PDR). This is the first systematic review and meta-analysis to assess the impact of PDR on treatment outcomes among people initiating nonnucleoside reverse transcriptase inhibitor (NNRTI)-based ART, including the combination of efavirenz (EFV), tenofovir (TDF), and lamivudine or emtricitabine (XTC). Methods. We systematically reviewed studies and conference proceedings comparing treatment outcomes in populations initiating NNRTI-based ART with and without PDR. We conducted subgroup analyses by regimen: (1) NNRTIs + 2 nucleoside reverse transcriptase inhibitors (NRTIs), (2) EFV + 2 NRTIs, or (3) EFV/TDF/XTC; by population (children vs adults); and by definition of resistance (PDR vs NNRTI PDR). Results. Among 6197 studies screened, 32 were analyzed (31 441 patients). We found that individuals with PDR initiating NNRTIs across all the subgroups had increased risk of virological failure compared to those without PDR. Risk of acquisition of new resistance mutations and ART switch was also higher in people with PDR. Conclusions. This review shows poorer treatment outcomes in the presence of PDR, supporting the World Health Organization's recommendation to avoid using NNRTIs in countries where levels of PDR are high.

引用

页码：377 / 388

页数：12

共 50 条

[1]

[Anonymous], 2020, HIV MARK REP

[2] Pretreatment HIV-drug resistance in Mexico and its impact on the effectiveness of first-line antiretroviral therapy: a nationally representative 2015 WHO survey [J].

Avila-Rios, Santiago ;

Garcia-Morales, Claudia ;

Matias-Florentino, Margarita ;

Romero-Mora, Karla A. ;

Tapia-Trejo, Daniela ;

Quiroz-Morales, Veronica S. ;

Reyes-Gopar, Helena ;

Ji, Hezhao ;

Sandstrom, Paul ;

Casillas-Rodriguez, Jesus ;

Sierra-Madero, Juan ;

Leon-Juarez, Eddie A. ;

Valenzuela-Lara, Marisol ;

Magis-Rodriguez, Carlos ;

Uribe-Zuniga, Patricia ;

Reyes-Teran, Gustavo .

LANCET HIV, 2016, 3 (12) :E579-E591

[3] Dolutegravir-Based or Low-Dose Efavirenz-Based Regimen for the Treatment of HIV-1 [J].

Ayouba, A. ;

Butel, C. ;

Cournil, A. ;

Delaporte, E. ;

Eymard-Duvernay, S. ;

Granouillac, B. ;

Izard, S. ;

Lacroix, A. ;

Leroy, S. ;

Peeters, M. ;

Perrineau, S. ;

Serrano, L. ;

Reynes, J. ;

Tovar-Sanchez, T. ;

Vidal, N. ;

Fouda, P. J. ;

Kounfack, C. ;

Mougnoutou, R. ;

Olinga, J. ;

Omgba, V. ;

Ngande, S. C. Tchokonte ;

Ymele, B. ;

Mpacko, C. D. Epoupa ;

Mpoudi-Etame, M. ;

Fotso, M. ;

Moukoko, R. ;

Nke, T. ;

Akamba, A. ;

Bassega, P. Omgba ;

Fotack, S. B. Tongo ;

Ngono, S. ;

Tanga, M. ;

Aghokeng, A. ;

Ebong, E. ;

Mbesse, G. Edoul ;

Tsongo, M. ;

Mpoudi-Ngole, E. ;

Abong, T. ;

Ciaffi, L. ;

Koulla-Shiro, S. ;

Legac, S. ;

Lem, S. ;

Manirakiza, G. ;

Tata, D. Tetsa ;

Varloteaux, M. ;

Boyer, S. ;

Bousmah, M. ;

Maradan, G. ;

Nishimwe, M. L. ;

Spire, B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (09) :816-826

[4] Transmitted drug resistant HIV-1 and association with virologic and CD4 cell count response to combination Antiretroviral therapy in the EuroSIDA study [J].

Bannister, Wendy P. ;

Cozzi-Lepri, Alessandro ;

Clotet, Bonaventura ;

Mocroft, Amanda ;

Kjaer, Jesper ;

Reiss, Peter ;

von Wyl, Viktor ;

Lazzarin, Adriano ;

Katlama, Christine ;

Phillips, Andrew N. ;

Ruiz, Lidia ;

Lundgren, Jens D. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2008, 48 (03) :324-333

[5] The Impact of Transmitted Drug-Resistance on Treatment Selection and Outcome of First-Line Highly Active Antiretroviral Therapy (HAART) [J].

Bansi, Loveleen ;

Geretti, Anna Maria ;

Dunn, David ;

Hill, Teresa ;

Green, Hannah ;

Fearnhill, Esther ;

Gazzard, Brian ;

Nelson, Mark ;

Porter, Kholoud ;

Phillips, Andrew ;

Sabin, Caroline .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2010, 53 (05) :633-639

[6] Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update [J].

Bennett, Diane E. ;

Camacho, Ricardo J. ;

Otelea, Dan ;

Kuritzkes, Daniel R. ;

Fleury, Herve ;

Kiuchi, Mark ;

Heneine, Walid ;

Kantor, Rami ;

Jordan, Michael R. ;

Schapiro, Jonathan M. ;

Vandamme, Anne-Mieke ;

Sandstrom, Paul ;

Boucher, Charles A. B. ;

van de Vijver, David ;

Rhee, Soo-Yon ;

Liu, Tommy F. ;

Pillay, Deenan ;

Shafer, Robert W. .

PLOS ONE, 2009, 4 (03)

[7] Pretreatment HIV Drug Resistance Increases Regimen Switches in Sub-Saharan Africa [J].

Boender, T. Sonia ;

Hoenderboom, Bernice M. ;

Sigaloff, Kim C. E. ;

Hamers, Raph L. ;

Wellington, Maureen ;

Shamu, Tinei ;

Siwale, Margaret ;

Maksimos, Eman E. F. Labib ;

Nankya, Immaculate ;

Kityo, Cissy M. ;

Adeyemo, Titilope A. ;

Akanmu, Alani Sulaimon ;

Mandaliya, Kishor ;

Botes, Mariette E. ;

Ondoa, Pascale ;

de Wit, Tobias F. Rinke .

CLINICAL INFECTIOUS DISEASES, 2015, 61 (11) :1749-1758

[8] High levels of pre-treatment HIV drug resistance and treatment failure in Nigerian children [J].

Boerma, Ragna S. ;

Boender, T. Sonia ;

Sigaloff, Kim C. E. ;

de Wit, Tobias F. Rinke ;

van Hensbroek, Michael Boele ;

Ndembi, Nicaise ;

Adeyemo, Titilope ;

Temiye, Edamisan O. ;

Osibogun, Akin ;

Ondoa, Pascale ;

Calis, Job C. ;

Akanmu, Alani Sulaimon .

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2016, 19

[9] Baseline genotype as a predictor of virological failure to emtricitabine or stavudine in combination with didanosine and efavirenz [J].

Borroto-Esoda, Katyna ;

Waters, Joshua M. ;

Bae, Andrew S. ;

Harris, Jeanette L. ;

Hinkle, John E. ;

Quinn, Joseph B. ;

Rousseau, Frank S. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (08) :988-995

[10]

Chaix ML, 2007, ANTIVIR THER, V12, P1305

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