TRPM7 Is Required for Breast Tumor Cell Metastasis

被引：181

作者：

Middelbeek, Jeroen

Kuipers, Arthur J.

Henneman, Linda ^{[6
]}

Visser, Daan ^{[6
]}

Eidhof, Ilse

van Horssen, Remco ^{[2
]}

Wieringa, Be ^{[2
]}

Canisius, Sander V. ^{[7
]}

Zwart, Wilbert ^{[9
]}

Wessels, Lodewyk F. ^{[8
]}

Sweep, Fred C. G. J. ^{[3
]}

Bult, Peter ^{[4
]}

Span, Paul N. ^{[5
]}

van Leeuwen, Frank N. ^{[1
]}

Jalink, Kees ^{[6
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mol Life Sci, Lab Pediat Oncol, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Nijmegen Ctr Mol Life Sci, Dept Cell Biol, Med Ctr, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, NL-6500 HB Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6500 HB Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Radiat Oncol, NL-6500 HB Nijmegen, Netherlands

[6] Netherlands Canc Inst, Div Cell Biol, Amsterdam, Netherlands

[7] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands

[8] Netherlands Canc Inst, Div Bioinformat & Stat, NL-1066 CX Amsterdam, Netherlands

[9] Canc Res UK, Cambridge Res Inst, Li Ka Shing Ctr, Cambridge, England

来源：

CANCER RESEARCH | 2012年 / 72卷 / 16期

关键词：

FOCAL ADHESIONS; PROTEIN-KINASE; MECHANOTRANSDUCTION; MIGRATION; CHANNELS; ACTOMYOSIN; PROLIFERATION; CONTRACTILITY; CYTOSKELETON; HOMEOSTASIS;

D O I：

10.1158/0008-5472.CAN-11-3863

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether TRPM7 activity contributes to cancer progression has not been established. Here we report that high levels of TRPM7 expression independently predict poor outcome in breast cancer patients and that it is functionally required for metastasis formation in a mouse xenograft model of human breast cancer. Mechanistic investigation revealed that TRPM7 regulated myosin II-based cellular tension, thereby modifying focal adhesion number, cell-cell adhesion and polarized cell movement. Our findings therefore suggest that TRPM7 is part of a mechanosensory complex adopted by cancer cells to drive metastasis formation. Cancer Res; 72(16); 4250-61. (c) 2012 AACR.

引用

页码：4250 / 4261

页数：12

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