Gastrointestinal polyps and cancer in Peutz-Jeghers syndrome: clinical aspects

被引：30

作者：

Latchford, A. R. ^{[1
,2
]}

Phillips, R. K. S. ^{[2
]}

机构：

[1] Derriford Hosp, Dept Gastroenterol, Plymouth PL6 8DH, Devon, England

[2] St Marks Hosp, Polyposis Registry, Harrow, Middx, England

来源：

FAMILIAL CANCER | 2011年 / 10卷 / 03期

关键词：

Surveillance; Cancer; Peutz-Jeghers syndrome; Polyp; VIDEO CAPSULE ENDOSCOPY; SMALL-BOWEL POLYPS; OF-THE-LITERATURE; HAMARTOMATOUS POLYPS; COLORECTAL-CANCER; INCREASED RISK; MANAGEMENT; SURVEILLANCE; LKB1; CYCLOOXYGENASE-2;

D O I：

10.1007/s10689-011-9442-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The two main problems in the management of the gastrointestinal tract in patients with Peutz-Jeghers syndrome (PJS) are the long term cancer risk and managing polyp related complications, such as intussusception and bleeding. In this article we will focus mainly on the clinical management of these problems. We will highlight some of the controversies regarding gastrointestinal PJS polyps, cancer development and cancer risk. We will review the available literature, particularly focusing on clinical data, to provide insights into these controversies. We describe guidelines for the surveillance and management of gastrointestinal polyps in PJS and review the data behind current recommendations.

引用

页码：455 / 461

页数：7

共 49 条

[41]

Peutz J., 1921, NED TIJDSCHR GENEES, V10, P134

[42] Feasibility of Video Capsule Endoscopy in the Management of Children With Peutz-Jeghers Syndrome: A Blinded Comparison With Barium Enterography for the Detection of Small Bowel Polyps [J].

Postgate, Aymer ;

Hyer, Warren ;

Phillips, Robin ;

Gupta, Arun ;

Burling, David ;

Bartram, Clive ;

Marshall, Michelle ;

Taylor, Stuart ;

Brown, Gregor ;

Schofield, Gill ;

Bassett, Paul ;

Spray, Christine ;

Fitzpatrick, Aine ;

Fraser, Chris ;

Latchford, A. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2009, 49 (04) :417-423

[43] STK11 genotyping and cancer risk in Peutz-Jeghers syndrome [J].

Schumacher, V ;

Vogel, T ;

Leube, B ;

Driemel, C ;

Goecke, T ;

Möslein, G ;

Royer-Pokora, B .

JOURNAL OF MEDICAL GENETICS, 2005, 42 (05) :428-435

[44] EPITHELIAL MISPLACEMENT IN PEUTZ-JEGHERS POLYPS A DIAGNOSTIC PITFALL [J].

SHEPHERD, NA ;

BUSSEY, HJR ;

JASS, JR .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1987, 11 (10) :743-749

[45] CANCER AND THE PEUTZ-JEGHERS SYNDROME [J].

SPIGELMAN, AD ;

MURDAY, V ;

PHILLIPS, RKS .

GUT, 1989, 30 (11) :1588-1590

[46] Supression of Peutx-Jeghers polyposis by inhibition of cyclooxygenase-2 [J].

Udd, L ;

Katajisto, P ;

Rossi, DJ ;

Lepistö, A ;

Lahesmaa, AM ;

Ylikorkala, A ;

Järvinen, HJ ;

Ristimäki, AP ;

Mäkelä, TP .

GASTROENTEROLOGY, 2004, 127 (04) :1030-1037

[47]

UTSUNOMIYA J, 1975, JOHNS HOPKINS MED J, V136, P71

[48] Extraintestinal polyps in Peutz-Jeghers syndrome:: presentation of four cases and review of the literature [J].

Vogel, T ;

Schumacher, V ;

Saleh, A ;

Trojan, J ;

Möslein, G .

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2000, 15 (02) :118-123

[49] Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling [J].

Wei, Chongjuan ;

Amos, Christopher I. ;

Zhang, Nianxiang ;

Wang, Xiaopei ;

Rashid, Asif ;

Walker, Cheryl L. ;

Behringer, Richard R. ;

Frazier, Marsha L. .

CLINICAL CANCER RESEARCH, 2008, 14 (04) :1167-1171

← 1 2 3 4 5 →