Splenomegaly: Pathophysiological bases and therapeutic options

被引：69

作者：

McKenzie, Campbell V. ^{[1
]}

Colonne, Chanukya K. ^{[1
]}

Yeo, Jia Hao ^{[1
,2
]}

Fraser, Stuart T. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Sydney, Sch Med Sci, Discipline Physiol, Lab Blood Cell Dev, Camperdown, NSW, Australia

[2] Univ Sydney, Sch Med Sci, Discipline Anat & Histol, Camperdown, NSW, Australia

[3] Univ Sydney, Australian Inst Nanoscale Sci & Technol, Camperdown, NSW, Australia

[4] Univ Sydney, Sch Med Sci, Bosch Inst, Camperdown, NSW, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2018年 / 94卷

关键词：

Spleen; Splenomegaly; Congestion; Infiltration; Work hypertrophy; GAUCHER-DISEASE; SPLEEN ENLARGEMENT; PREGNANCY; MYELOFIBROSIS; SIZE;

D O I：

10.1016/j.biocel.2017.11.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The spleen is the largest immune organ in the human body and is also essential for red blood cell homeostasis and iron recycling. An average human spleen is approximately 10 centimetres in length and weighs 150 g. Pathological conditions can result in the spleen weighing in excess of 2000 g and extending over 30 centrimetres in length. This remarkable property of the spleen to expand is termed splenomegaly. Splenomegaly can occur as a physiological response to stress or as a chronic process that is often detrimental to the wellbeing of the individual. Here, we will discuss the normal function and physiology of the spleen, the pathophysiological bases of splenomegaly and the commonly available therapeutic options. Additionally we will address experimental systems to determine the regulatory mechanisms underlying splenomegaly.

引用

页码：40 / 43

页数：4

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