Association study of parathyroid hormone gene polymorphism and bone mineral density in Japanese postmenopausal women

被引:95
作者
Hosoi, T
Miyao, M
Inoue, S
Hoshino, S
Shiraki, M
Orimo, H
Ouchi, Y
机构
[1] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Bunkyo Ku, Tokyo 113, Japan
[2] Res Inst & Practice Involut Dis, Nagano, Japan
[3] Tokyo Metropolitan Geriatr Hosp, Tokyo 173, Japan
关键词
bone mineral density; osteoporosis; parathyroid hormone gene; polymorphism; risk factors;
D O I
10.1007/s002239900603
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Association of BST B1 restriction fragment length polymorphism (RFLP) of the parathyroid hormone (PTH) gene with bone mineral density (BMD) was examined in 383 healthy postmenopausal women in Japan who were unrelated. The RFLP was represented as B or b, the capital letter signifying the presence of and the small letter the absence of restriction site for BST B1. The frequency of each genotype-BB, Bb, and bb-was 82.5%, 16.7%, and 0.8% respectively. When we statistically compared age, years after menopause, body height, and body weight between the BE genotype and the Bb genotype groups, there was no significant difference between the groups. However, the lumbar BMD and the score of BMD adjusted for age and body weight (Z score) were significantly lower in the group of genotype Bb than in the BE: 0.859 +/- 0.019 g/cm(2) versus 0.925 +/- 0.011 (mean +/- SE, P = 0.01) and -0.412 +/- 0.138 versus 0.067 +/- 0.082 (mean +/- SE, P = 0.01). Ln addition, the Z score of total body BMD in the Bb genotype group was lower than that in the BE group. Comparison of serum and urinary biochemical bone metabolic markers suggested that the subjects with Bb genotype might be in a relatively higher state of bone turnover than those with BE genotype. These results suggest that the polymorphism in the PTH gene would be a useful genetic marker for lower BMD and the susceptibility for osteoporosis.
引用
收藏
页码:205 / 208
页数:4
相关论文
共 50 条
[41]   Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: The OFELY study [J].
Garnero, P ;
Borel, O ;
Sornay-Rendu, E ;
Duboeuf, F ;
Jeffery, R ;
Woo, P ;
Delmas, PD .
BONE, 2002, 31 (01) :43-50
[42]   Association of KIT gene polymorphisms with bone mineral density in postmenopausal Korean women [J].
Kim, Shin-Yoon ;
Lee, Jong-Young ;
Kim, Ha Young ;
Oh, Bermseok ;
Kimm, Kuchan ;
Kim, Hyung-Lae ;
Park, Byung Lae ;
Shin, Hyoung Doo ;
Park, Eui Kyun ;
Koh, Jung-Min ;
Kim, Ghi Su .
JOURNAL OF HUMAN GENETICS, 2007, 52 (06) :502-509
[43]   Cannabinoid receptor 2 gene polymorphism was associated with bone mineral density and t-score in Chinese postmenopausal women [J].
Hu, Xilian ;
Xie, Haibao ;
Yang, Quanshen ;
Wang, Yazhen ;
Mao, Gengxiang ;
Xu, Weihong ;
Lv, Yuandong ;
Wen, Xiaolin ;
Tao, Pinghua ;
Lin, Bing ;
Wang, Guofu ;
Yan, Jing .
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, 6 (02) :119-124
[44]   Association between periodontitis and systemic bone mineral density in Japanese community-dwelling postmenopausal women [J].
Takahashi, Osamu ;
Yoshihara, Akihiro ;
Nakamura, Kazutoshi ;
Miyazaki, Hideo .
JOURNAL OF DENTISTRY, 2012, 40 (04) :304-311
[45]   Association of the calcitonin gene (CA) polymorphism with bone mass and bone responsiveness to hormone therapy in postmenopausal Korean women [J].
Kim, JG ;
Choi, YM ;
Moon, SY ;
Lee, JY .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2003, 10 (06) :544-549
[46]   The association between sex hormone-binding globulin gene polymorphism with bone mineral density [J].
Zha, Xiao-Yun ;
Hu, Yu ;
Pang, Xiao-Na ;
Zhu, Ji-Heng ;
Chang, Gui-Lin ;
Li, Li .
STEROIDS, 2016, 106 :9-18
[47]   Relationship between bone mineral density and polymorphism of the estrogen receptor gene in healthy postmenopausal women in China [J].
Huang, QR ;
Wang, QH ;
Zhang, LP ;
Lu, JH ;
Zhou, Q ;
Liu, YJ ;
He, JW ;
Lin, FX .
CHINESE MEDICAL JOURNAL, 1999, 112 (09) :832-835
[48]   Estrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density [J].
Yavuz, D. G. ;
Yoldemir, T. ;
Ozaltun, K. ;
Erenus, M. .
CLIMACTERIC, 2012, 15 (04) :368-373
[49]   Association of TNFSF11 gene promoter polymorphisms with bone mineral density in postmenopausal women [J].
Mencej, Simona ;
Prezelj, Janez ;
Kocijancic, Andreja ;
Ostanek, Barbara ;
Marc, Janja .
MATURITAS, 2006, 55 (03) :219-226
[50]   Romosozumab increases bone mineral density in postmenopausal Japanese women with osteoporosis: A phase 2 study [J].
Ishibashi, Hideaki ;
Crittenden, Daria B. ;
Miyauchi, Akimitsu ;
Libanati, Cesar ;
Maddox, Judy ;
Fan, Michelle ;
Chen, Li ;
Grauer, Andreas .
BONE, 2017, 103 :209-215