Seroprevalence and correlates of hepatitis A among HIV-negative American men who have sex with men

被引:12
作者
Bialek, Stephanie R. [1 ]
Barry, Vaughn [1 ]
Bell, Beth P. [1 ]
Valleroy, Linda A. [2 ]
Behel, Stephanie [2 ]
MacKellar, Duncan A. [2 ]
Secura, Gina [2 ]
Thiede, Hanne [3 ]
McFarland, Willi [4 ]
Ford, Wesley L. [5 ]
Bingham, Trista A. [5 ]
Shehan, Douglas A. [6 ]
Celentano, David D. [7 ]
机构
[1] Ctr Dis Control & Prevent CDC, Div Viral Dis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30030 USA
[2] CDC, Div HIV AIDS Prevent, NCHHSTP, Atlanta, GA 30030 USA
[3] Publ Hlth Seattle Seattle WA & King Cty, Seattle, WA 98104 USA
[4] San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
[5] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA 90012 USA
[6] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA
[7] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA
关键词
hepatitis A; hepatitis A vaccination; MSM; prevalence; USA; young men's study; INJECTION-DRUG USERS; HOMOSEXUAL-MEN; RISK-FACTORS; YOUNG MEN; INFECTION; OUTBREAK; VACCINATION; VIRUS; PREVALENCE; AMSTERDAM;
D O I
10.1071/SH10162
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Hepatitis A outbreaks are well documented among men who have sex with men (MSM). This analysis examines characteristics associated with hepatitis A virus (HAV) infection among a large group of young adult MSM from five USA cities. Methods: The Young Men's Survey was a cross-sectional prevalence study of HIV infection and related behavioural risk factors among MSM aged 15-29 years during 1994-2000. Serum specimens from HIV-negative participants were retrospectively tested for antibodies to HAV (anti-HAV). Data were stratified by ethnicity and analysed with logistic regression. Results: Overall anti-HAV prevalence was 18.4% among the 2708 participants, and varied by ethnicity from 6.9 to 45.3% and was highest among Hispanic and Asian men (P < 0.001). Prevalence increased with age across all racial/ethnic groups. Among white men, anti-HAV positivity was associated with having 20 or more lifetime male sex partners for those aged 15-22 years (adjusted odds ratio (AOR) = 2.1, 95% confidence interval (CI) = 1.0-4.1) and ever having had unprotected anal sex for those aged 23-29 years (AOR = 2.4, 95% CI = 1.2-4.5). Conclusions: Factors associated with a history of HAV infection among MSM in non-outbreak settings are probably similar to those among non-MSM. MSM are still at risk for HAV infection as a result of outbreaks occurring in MSM communities. Additional studies of hepatitis A vaccination coverage are needed to determine if strategies to vaccinate MSM are adequate.
引用
收藏
页码:343 / 348
页数:6
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