Biomarkers in Neuropsychiatric Systemic Lupus Erythematosus: A Systematic Literature Review of the Last Decade

被引：23

作者：

Lindblom, Julius ^{[1
,2
]}

Mohan, Chandra ^{[3
]}

Parodis, Ioannis ^{[1
,2
,4
]}

机构：

[1] Karolinska Inst, Dept Med Solna, Div Rheumatol, S-17176 Stockholm, Sweden

[2] Karolinska Univ Hosp, S-17176 Stockholm, Sweden

[3] Univ Houston, Dept Biomed Engn, Houston, TX 77204 USA

[4] Orebro Univ, Dept Rheumatol, Fac Med & Hlth, S-70182 Orebro, Sweden

来源：

BRAIN SCIENCES | 2022年 / 12卷 / 02期

关键词：

systemic lupus erythematosus; neuropsychiatric systemic lupus erythematosus; biomarkers; diagnosis; monitoring; prognosis; CEREBROSPINAL-FLUID; NEUROLOGICAL-DISORDERS; I INTERFERON; TREX1; GENE; AUTOANTIBODIES; AUTOIMMUNE; KLOTHO; EXPRESSION; MARKERS; EVENTS;

D O I：

10.3390/brainsci12020192

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nervous system involvement in patients with SLE, termed neuropsychiatric SLE (NPSLE), constitutes a diagnostic challenge, and its management is still poorly optimised. This review summarises recent insights over the past decade in laboratory biomarkers of diagnosis, monitoring, and prognosis of NPSLE. An initial systematic search in the Medline and Web of Science was conducted to guide the selection of articles. Emerging diagnostic biomarkers in NPSLE that displayed satisfactory ability to discriminate between NPSLE and controls include serum interleukin (IL)-6, microRNA (miR)-23a, miR-155, and cerebrospinal fluid (CSF) alpha-Klotho. CSF lipocalin-2, macrophage colony-stimulating factor (M-CSF), and immunoglobulin (Ig)M also displayed such ability in two ethnically diverse cohorts. Serum interferon (IFN)-alpha and neuron specific enolase (NSE) were recently reported to moderately correlate with disease activity in patients with active NPSLE. CSF IL-8, IL-13, and granulocyte colony-stimulating factor (G-CSF) exhibited excellent sensitivity, yet poorer specificity, as predictors of response to therapy in patients with NPSLE. The overall lack of validation studies across multiple and diverse cohorts necessitates further and well-concerted investigations. Nevertheless, we propound CSF lipocalin 2 among molecules that hold promise as reliable diagnostic biomarkers in NPSLE.

引用

页数：13

共 78 条

[31] Novel anti-suprabasin antibodies may contribute to the pathogenesis of neuropsychiatric systemic lupus erythematosus [J].

Ichinose, Kunihiro ;

Ohyama, Kaname ;

Furukawa, Kaori ;

Higuchi, Osamu ;

Mukaino, Akihiro ;

Satoh, Katsuya ;

Nakane, Shunya ;

Shimizu, Toshimasa ;

Umeda, Masataka ;

Fukui, Shoichi ;

Nishino, Ayako ;

Nakajima, Hideki ;

Koga, Tomohiro ;

Kawashiri, Shin-ya ;

Iwamoto, Naoki ;

Tamai, Mami ;

Nakamura, Hideki ;

Origuchi, Tomoki ;

Yoshida, Mari ;

Kuroda, Naotaka ;

Kawakami, Atsushi .

CLINICAL IMMUNOLOGY, 2018, 193 :123-130

[32] Predictors of clinical outcomes in patients with neuropsychiatric systemic lupus erythematosus [J].

Ichinose, Kunihiro ;

Arima, Kazuhiko ;

Umeda, Masataka ;

Fukui, Shoichi ;

Nishino, Ayako ;

Nakashima, Yoshikazu ;

Suzuki, Takahisa ;

Horai, Yoshiro ;

Koga, Tomohiro ;

Kawashiri, Shin-ya ;

Iwamoto, Naoki ;

Fujikawa, Keita ;

Aramaki, Toshiyuki ;

Tamai, Mami ;

Nakamura, Hideki ;

Sato, Shuntaro ;

Origuchi, Tomoki ;

Kawakami, Atsushi .

CYTOKINE, 2016, 79 :31-37

[33] Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases [J].

Ichinose, Kunihiro ;

Arima, Kazuhiko ;

Ushigusa, Takeshi ;

Nishino, Ayako ;

Nakashima, Yoshikazu ;

Suzuki, Takahisa ;

Horai, Yoshiro ;

Nakajima, Hideki ;

Kawashiri, Shin-ya ;

Iwamoto, Naoki ;

Tamai, Mami ;

Nakamura, Hideki ;

Origuchi, Tomoki ;

Motomura, Masakatsu ;

Kawakami, Atsushi .

CLINICAL IMMUNOLOGY, 2015, 157 (02) :114-120

[34] Association of serial biochemical markers with acute ischemic stroke - The National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study [J].

Jauch, Edward C. ;

Lindsell, Christopher ;

Broderick, Joseph ;

Fagan, Susan C. ;

Tilley, Barbara C. ;

Levine, Steven R. .

STROKE, 2006, 37 (10) :2508-2513

[35] Risk factors for central nervous system involvement in systemic lupus erythematosus [J].

Karassa, FB ;

Ioannidis, JPA ;

Touloumi, G ;

Boki, KA ;

Moutsopoulos, HM .

QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, 2000, 93 (03) :169-174

[36] New roles for the major human 3′-5′ exonuclease TREX1 in human disease [J].

Kavanagh, David ;

Spitzer, Dirk ;

Kothari, Parul H. ;

Shaikh, Aisha ;

Liszewski, M. Kathryn ;

Richards, Anna ;

Atkinson, John P. .

CELL CYCLE, 2008, 7 (12) :1718-1725

[37] Utility of osteopontin in cerebrospinal fluid as a diagnostic marker for neuropsychiatric systemic lupus erythematosus [J].

Kitagori, K. ;

Yoshifuji, H. ;

Oku, T. ;

Ayaki, T. ;

Kuzuya, A. ;

Nakajima, T. ;

Akizuki, S. ;

Nakashima, R. ;

Murakami, K. ;

Ohmura, K. ;

Hirayama, Y. ;

Takahashi, R. ;

Mimori, T. .

LUPUS, 2019, 28 (03) :414-422

[38] CSF parameters associated with early MRI activity in patients with MS [J].

Klein, Ana ;

Selter, Rebecca C. ;

Hapfelmeier, Alexander ;

Berthele, Achim ;

Mueller-Myhsok, Bertram ;

Pongratz, Viola ;

Gasperi, Christiane ;

Zimmer, Claus ;

Muehlau, Mark ;

Hemmer, Bernhard .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2019, 6 (04)

[39] Plasma S100β and NSE levels and progression in multiple sclerosis [J].

Koch, Marcus ;

Mostert, Jop ;

Heersema, Dorothea ;

Teelken, Albert ;

De Keyser, Jacques .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2007, 252 (02) :154-158

[40] Depression, fatigue, and pain in systemic lupus erythematosus (SLE): Relationship to the American College of Rheumatology SLE neuropsychological battery [J].

Kozora, Elizabeth ;

Ellison, Misoo C. ;

West, Sterling .

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2006, 55 (04) :628-635

← 1 2 3 4 5 6 7 8 →