Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum

被引：116

作者：

Kim, YP

Lee, EB

Kim, SY

Li, DW

Ban, HS

Lim, SS

Shin, KH

Ohuchi, K

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Lab Pathophysiol Biochem, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Seoul Natl Univ, Inst Nat Prod Res, Seoul, South Korea

来源：

PLANTA MEDICA | 2001年 / 67卷 / 04期

关键词：

D O I：

10.1055/s-2001-14317

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Platycodin D, isolated from the root of Platycodon grandiflorum A. DC. (Campanulaceae) suppressed prostaglandin E-2 production at 10 and 30 muM in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA). Platycodin D-3 and oleanolic acid showed no effect at these concentrations. Western blot analysis revealed that the induction of COX-2 protein by TPA was inhibited by platycodin D in parallel with the inhibition of prostaglandin E-2 production. Platycodin D showed no direct effect on COX-1 and COX-2 activities. TPA-induced release of [H-3]arachidonic acid from pre-labeled macrophages was also not inhibited by platycodin D.

引用

页码：362 / 364

页数：3

共 7 条

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[2] Inhibition by tectorigenin and tectoridin of prostaglandin E2 production and cyclooxygenase-2 induction in rat peritoneal macrophages [J].