Designs from the deep: Marine organisms for bone tissue engineering

被引:58
作者
Clarke, S. A. [1 ]
Walsh, P. [1 ]
Maggs, C. A. [1 ]
Buchanan, F. [2 ]
机构
[1] Queens Univ Belfast, Sch Biol Sci, Ctr Med Biol, Belfast, Antrim, North Ireland
[2] Queens Univ Belfast, Sch Mech & Aerosp Engn, Belfast, Antrim, North Ireland
关键词
Bone; Tissue engineering; Calcium phosphate; Bone graft; Ceramics; OSTEOBLAST-LIKE CELLS; IN-VITRO; HYDROXYAPATITE SCAFFOLDS; MECHANICAL-PROPERTIES; TRICALCIUM PHOSPHATE; SPONGIA-OFFICINALIS; GRAFT SUBSTITUTE; CALCIUM; CORAL; GROWTH;
D O I
10.1016/j.biotechadv.2011.04.003
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Current strategies for bone repair have accepted limitations and the search for synthetic graft materials or for scaffolds that will support ex vivo bone tissue engineering continues. Biomimetic strategies have led to the investigation of naturally occurring porous structures as templates for bone growth. The marine environment is rich in mineralizing organisms with porous structures, some of which are currently being used as bone graft materials and others that are in early stages of development. This review describes the current evidence available for these organisms, considers the relative promise of each and suggests potential future directions. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:610 / 617
页数:8
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