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Translational selection on codon usage in Xenopus laevis
被引:53
作者:
Musto, H
Cruveiller, W
D'Onofrio, G
Romero, H
Bernardi, G
机构:
[1] Staz Zool Anton Dohrn, Lab Evoluz Mol, I-80121 Naples, Italy
[2] Fac Ciencias, Secc Bioquim, Lab Org & Evoluc Genoma, Montevideo, Uruguay
[3] Fac Med, Dept Genet, Montevideo, Uruguay
关键词:
codon usage;
isochores;
translational selection;
vertebrates;
correspondence analysis;
D O I:
10.1093/oxfordjournals.molbev.a003958
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
A correspondence analysis of codon usage in Xenopus laevis revealed that the first axis is strongly correlated with the base composition at third codon positions. The second axis discriminates between putatively highly expressed genes and the other coding sequences, with expression levels being confirmed by the analysis of Expressed sequence tag frequencies. The comparison of codon usage of the sequences displaying the extreme values on the second axis indicates that several codons are statistically more frequent among the highly expressed (mainly housekeeping) genes. Translational selection appears, therefore, to influence synonymous codon usage in Xenopus.
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页码:1703 / 1707
页数:5
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