Human Leukocyte Antigen Typing by Next-Generation Sequencing

被引：30

作者：

Profaizer, Tracie ^{[1
]}

Kumanovics, Attila ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Pathol, ARUP Inst Clin & Expt Pathol, 500 Chipeta Way, Salt Lake City, UT 84108 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2018年 / 38卷 / 04期

关键词：

Human leukocyte antigen (HLA); Next generation sequencing (NGS); DNA sequencing; Polymerase chain reaction (PCR); HIGH-RESOLUTION; PERFORMANCE-CHARACTERISTICS; LIBRARY CONSTRUCTION; HUMAN GENOME; ION TORRENT; HLA; DNA; NANOPORE; IDENTIFICATION; COMPLEX;

D O I：

10.1016/j.cll.2018.07.006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Human leukocyte antigen (HLA) allele ambiguities are the result of limitations of current HLA typing methodologies. Ambiguities maybe due to polymorphisms in unsequenced regions of HLA genes or cis/trans variants that cannot be distinguished by Sanger sequencing. Next generation sequencing (NGS) can resolve these two sources of ambiguity because the entire gene can be sequenced. Commercially available HLA NGS genotyping kits enable laboratories to deliver high-quality and unambiguous HLA typing results at an affordable cost. Third generation sequencing technologies are poised to further improve sequencing quality, shorten turn-around and library preparation times, as well as provide full-gene phasing.

引用

页码：565 / +

页数：15

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