Synthesis of imidazo[1',2':3,4]pyrimido[6,1-alpha]isoquinoline and pyrimido[1',2':3,4]pyrimido[6,1-alpha]isoquinoline ring systems by tandem cyclization.

被引：0

作者：

Fulop, F

Wamhoff, H

Sohar, P

机构：

[1] UNIV BONN, INST ORGAN CHEM & BIOCHEM, D-53121 BONN, GERMANY

[2] EOTVOS LORAND UNIV, ALTALANOS & SZERVETLEN KEM TANSZEK, H-1518 BUDAPEST, HUNGARY

来源：

MAGYAR KEMIAI FOLYOIRAT | 1996年 / 102卷 / 11期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reactions of 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinoline-1-acetonitrile 3 and 4 with 2-chloroethyl and 3-chloropropyl isocyanates resulted in urethanes 5-8, which were transformed with sodium methylate into the new ring systems 9.10-dimethoxy- and 9,10-diethoxy-5H-2,3,7,8,12b, 13-hexahydroimidazo[1',2':3,4]pyrimido[6,1-a]isoquin olin-5-one (9, 10) and 11,12-dimethoxy- and 11,12-diethoxy-2H, 6H-3,4,8,9,13b,14-hexahydropyrimido [1',2':3,4]pyrimido[6,1-a]isoquinolin-6-one (11, 12), by tandem cyclization.

引用

页码：477 / 483

页数：7

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