DNA-Based Nanobiosensors as an Emerging Platform for Detection of Disease

被引：92

作者：

Abu-Salah, Khalid M. ^{[1
,2
,3
]}

Zourob, Mohammed M. ^{[4
]}

Mouffouk, Fouzi ^{[5
]}

Alrokayan, Salman A. ^{[1
,2
]}

Alaamery, Manal A. ^{[3
]}

Ansari, Anees A. ^{[2
]}

机构：

[1] King Saud Univ, Res Chair Med Applicat Nanomat, Riyadh 11451, Saudi Arabia

[2] King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia

[3] King Abdulla Int Med Res Ctr, Riyadh 11426, Saudi Arabia

[4] Alfaisal Univ, Dept Chem, Riyadh 11533, Saudi Arabia

[5] Kuwait Univ, Fac Sci, Dept Chem, Safat 13060, Kuwait

来源：

SENSORS | 2015年 / 15卷 / 06期

关键词：

DNA nanobiosensors; nanoparticles; cancer; genetic and infectious diseases; electrochemical and optical sensing; ELECTROCHEMICAL STRIPPING DETECTION; NUCLEIC-ACID; QUANTUM-DOT; AMPEROMETRIC DETECTION; COLORIMETRIC DETECTION; SULFIDE NANOPARTICLE; SILICA NANOPARTICLES; ELECTRICAL DETECTION; CARBON NANOTUBES; HIGH-SENSITIVITY;

D O I：

10.3390/s150614539

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Detection of disease at an early stage is one of the biggest challenges in medicine. Different disciplines of science are working together in this regard. The goal of nanodiagnostics is to provide more accurate tools for earlier diagnosis, to reduce cost and to simplify healthcare delivery of effective and personalized medicine, especially with regard to chronic diseases (e.g., diabetes and cardiovascular diseases) that have high healthcare costs. Up-to-date results suggest that DNA-based nanobiosensors could be used effectively to provide simple, fast, cost-effective, sensitive and specific detection of some genetic, cancer, and infectious diseases. In addition, they could potentially be used as a platform to detect immunodeficiency, and neurological and other diseases. This review examines different types of DNA-based nanobiosensors, the basic principles upon which they are based and their advantages and potential in diagnosis of acute and chronic diseases. We discuss recent trends and applications of new strategies for DNA-based nanobiosensors, and emphasize the challenges in translating basic research to the clinical laboratory.

引用

页码：14539 / 14568

页数：30

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