DNA-Based Nanobiosensors as an Emerging Platform for Detection of Disease

被引：92
作者：
Abu-Salah, Khalid M. [1 ,2 ,3 ]
Zourob, Mohammed M. [4 ]
Mouffouk, Fouzi [5 ]
Alrokayan, Salman A. [1 ,2 ]
Alaamery, Manal A. [3 ]
Ansari, Anees A. [2 ]
机构：
[1] King Saud Univ, Res Chair Med Applicat Nanomat, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia
[3] King Abdulla Int Med Res Ctr, Riyadh 11426, Saudi Arabia
[4] Alfaisal Univ, Dept Chem, Riyadh 11533, Saudi Arabia
[5] Kuwait Univ, Fac Sci, Dept Chem, Safat 13060, Kuwait
来源：
SENSORS | 2015年 / 15卷 / 06期
关键词：
DNA nanobiosensors; nanoparticles; cancer; genetic and infectious diseases; electrochemical and optical sensing; ELECTROCHEMICAL STRIPPING DETECTION; NUCLEIC-ACID; QUANTUM-DOT; AMPEROMETRIC DETECTION; COLORIMETRIC DETECTION; SULFIDE NANOPARTICLE; SILICA NANOPARTICLES; ELECTRICAL DETECTION; CARBON NANOTUBES; HIGH-SENSITIVITY;
D O I：
10.3390/s150614539
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Detection of disease at an early stage is one of the biggest challenges in medicine. Different disciplines of science are working together in this regard. The goal of nanodiagnostics is to provide more accurate tools for earlier diagnosis, to reduce cost and to simplify healthcare delivery of effective and personalized medicine, especially with regard to chronic diseases (e.g., diabetes and cardiovascular diseases) that have high healthcare costs. Up-to-date results suggest that DNA-based nanobiosensors could be used effectively to provide simple, fast, cost-effective, sensitive and specific detection of some genetic, cancer, and infectious diseases. In addition, they could potentially be used as a platform to detect immunodeficiency, and neurological and other diseases. This review examines different types of DNA-based nanobiosensors, the basic principles upon which they are based and their advantages and potential in diagnosis of acute and chronic diseases. We discuss recent trends and applications of new strategies for DNA-based nanobiosensors, and emphasize the challenges in translating basic research to the clinical laboratory.
引用
收藏
页码：14539 / 14568
页数：30
相关论文
共 147 条
[41]   Graphene-based materials for biosensing and bioimaging [J].
Du, Dan ;
Yang, Yuqi ;
Lin, Yuehe .
MRS BULLETIN, 2012, 37 (12) :1290-1296
[42]   In vivo imaging of quantum dots encapsulated in phospholipid micelles [J].
Dubertret, B ;
Skourides, P ;
Norris, DJ ;
Noireaux, V ;
Brivanlou, AH ;
Libchaber, A .
SCIENCE, 2002, 298 (5599) :1759-1762
[43]   Nanomedicine(s) under the Microscope [J].
Duncan, Ruth ;
Gaspar, Rogerio .
MOLECULAR PHARMACEUTICS, 2011, 8 (06) :2101-2141
[44]  
Dutse SW, 2013, INT J ELECTROCHEM SC, V8, P11048
[45]   Quenching of CdSe quantum dot emission, a new approach for biosensing [J].
Dyadyusha, L ;
Yin, H ;
Jaiswal, S ;
Brown, T ;
Baumberg, JJ ;
Booy, FP ;
Melvin, T .
CHEMICAL COMMUNICATIONS, 2005, (25) :3201-3203
[46]   SPONTANEOUSLY FORMED FUNCTIONALLY ACTIVE AVIDIN MONOLAYERS ON METAL-SURFACES - A STRATEGY FOR IMMOBILIZING BIOLOGICAL REAGENTS AND DESIGN OF PIEZOELECTRIC BIOSENSORS [J].
EBERSOLE, RC ;
MILLER, JA ;
MORAN, JR ;
WARD, MD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (08) :3239-3241
[47]   Thermostable Luciferase from Luciola cruciate for Imaging of Carbon Nanotubes and Carbon Nanotubes Carrying Doxorubicin Using in Vivo Imaging System [J].
El-Sayed, Ramy ;
Eita, Mohamed ;
Barrefelt, Asa ;
Ye, Fei ;
Jain, Himanshu ;
Fares, Mona ;
Lundin, Arne ;
Crona, Mikael ;
Abu-Salah, Khalid ;
Muhammed, Mamoun ;
Hassan, Moustapha .
NANO LETTERS, 2013, 13 (04) :1393-1398
[48]   Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles [J].
Elghanian, R ;
Storhoff, JJ ;
Mucic, RC ;
Letsinger, RL ;
Mirkin, CA .
SCIENCE, 1997, 277 (5329) :1078-1081
[49]   Novel hybridization indicator methylene blue for the electrochemical detection of short DNA sequences related to the hepatitis B virus [J].
Erdem, A ;
Kerman, K ;
Meric, B ;
Akarca, US ;
Ozsoz, M .
ANALYTICA CHIMICA ACTA, 2000, 422 (02) :139-149
[50]  
Estévez MC, 2009, NANO RES, V2, P448, DOI [10.1007/S12274-009-9041-8, 10.1007/s12274-009-9041-8]
12345678910