Hypoxia-induced secretion of macrophage migration-inhibitory factor from MCF-7 breast cancer cells is regulated in a hypoxia-inducible factor-independent manner

被引：31

作者：

Larsen, Mona ^{[2
]}

Tazzyman, Simon ^{[3
]}

Lund, Eva L. ^{[2
]}

Junker, Nanna ^{[2
]}

Lewis, Claire E. ^{[3
]}

Kristjansen, Paul E. G. ^{[2
]}

Murdoch, Craig ^{[1
]}

机构：

[1] Univ Sheffield, Sch Clin Dent, Dept Oral & Maxillofacial Surg, Sheffield, S Yorkshire, England

[2] Univ Copenhagen, Inst Mol Pathol, Expt Oncol Lab, Copenhagen, Denmark

[3] Univ Sheffield, Sch Med, Div Genom Med, Acad Unit Pathol,Tumor Targeting Grp, Sheffield, S Yorkshire, England

来源：

CANCER LETTERS | 2008年 / 265卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

macrophage migration-inhibitory factor; hypoxia; hypoxia-inducible factor; breast cancer;

D O I：

10.1016/j.canlet.2008.02.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cytokine MIF is over-expressed in tumors and is associated with tumor proliferation, angiogenesis and metastasis. Hypoxia, a hallmark feature of tumors, increases MIF expression from tumor cells. We examined the role of hypoxia-inducible transcription factors on MIF secretion from MCF-7 breast carcinoma cells. Secretion of MIF was induced by hypoxia after 24 h but up-regulation of MIF mRNA was minimal. Inhibition of HIF-1 alpha, HIF-2 alpha, NF-kappa B and C/EBP beta using siRNA had no effect on hypoxia-induced MIF secretion. However, inhibition of transcription and translation significantly decreased MIF production, suggesting that hypoxia-induced secretion of MIF in MCF-7 cells is via an alternative pathway. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：239 / 249

页数：11

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