EFFECT OF THE ROUTE OF FOOT-AND-MOUTH DISEASE VIRUS INFECTION OF PIGLETS ON THE COURSE OF DISEASE

被引：0

作者：

Li, D. ^{[1
]}

Bai, X. -W. ^{[1
]}

Sun, P. ^{[1
]}

Fu, Y. -F. ^{[1
]}

Xie, B. -X. ^{[1
]}

Lu, Z. -J. ^{[1
]}

Chen, Y. -L. ^{[1
]}

Cao, W. -J. ^{[1
]}

Liu, Z. -X. ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Key Lab Anim Virol,Minist Agr,Natl Foot & Mouth D, Lanzhou 730046, Gansu, Peoples R China

来源：

ACTA VIROLOGICA | 2010年 / 54卷 / 04期

关键词：

Foot-and-mouth disease virus; challenge routes; intranasal drops; intradermal injection; intramuscular injection; pig; HONG-KONG;

D O I：

10.4149/av_2010_04_311

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Three different routes of Foot-and-mouth disease virus (FMDV) infection of piglets, namely intranasal (i.n.) through drops, intradermal (i.d.) into the foot, and intramuscular (i.m.) were compared regarding the onset and severity of the disease. The results showed that the id. injection of the virus resulted in the fastest onset of the disease. The i.m. injection led to a delayed onset, but the final effect was identical with i.d. injection. Moreover, the i.m. injection was simpler to perform and easier to evaluate. Therefore, the i.m. injection of piglets is recommended as the optimal infection route for evaluation of the FMDV vaccine potency.

引用

页码：311 / 313

页数：3

共 9 条

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