Aporphine alkaloids from Guatteria stenopetala (Annonaceae)

被引：0

作者：

Rodriguez, Maria ^{[1
]}

Bastidas, Elsy ^{[1
]}

Rodriguez, Mildred ^{[1
]}

Lucena, Edgar ^{[1
]}

Castillo, Anibal ^{[2
]}

Hasegawa, Masahisa ^{[1
]}

机构：

[1] Cent Univ Venezuela, Lab Prod Nat, Escuela Quim, Fac Ciencias, Caracas 1020A, Venezuela

[2] Cent Univ Venezuela, Ctr Bot Trop,Inst Biol Expt, Escuela Biol, Fac Ciencias, Caracas 1020A, Venezuela

来源：

NATURAL PRODUCT COMMUNICATIONS | 2008年 / 3卷 / 04期

关键词：

Guatteria stenopetala; dicentrinone; N-methyldicentrinone; 4,5-dioxoaporphine; aporphine alkaloids; Annonaceae; MAO-B;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Guatteria species (Annonaceae) are rich in isoquinoline alkaloids that contain a restricted beta-phenethylamine moiety and thus have potential as monoamine oxidase (MAO) inhibitors for the treatment of Alzheimer's and Parkinson's diseases. Three aporphine alkaloids have been isolated from G. stenopetala, the known oxoaporphine dicentrinone (1), and two novel compounds, N-methyldicentrinone (2) and 4,5-dioxodehydrodicentrine (3). Their inhibitory effects on MAO-B were evaluated, but none of them was significantly active.

引用

页码：515 / 518

页数：4

共 13 条

[1] DEHYDROOCOPODINE, DICENTRINONE, AND OTHER ALKALOIDS FROM OCOTEA-MACROPODA AND HERNANDIA-JAMAICENSIS [J].

CAVA, MP ;

VENKATES.A .

TETRAHEDRON, 1971, 27 (13) :2639-&

[2] NORTHALIFOLINE, A NEW ISOQUINOLONE ALKALOID FROM THE PEDICELS OF LINDERA-MEGAPHYLLA [J].

CHOU, CJ ;

LIN, LC ;

CHEN, KT ;

CHEN, CF .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (06) :689-694

[3] A rapid diversification of rainforest trees (Guatteria; Annonaceae) following dispersal from Central into South America [J].

Erkens, Roy H. J. ;

Chatrou, Lars W. ;

Maas, Jan W. ;

van der Niet, Timotheus ;

Savolainen, Vincent .

MOLECULAR PHYLOGENETICS AND EVOLUTION, 2007, 44 (01) :399-411

[4]

GUINAUDEAU H, 1988, J NAT PRODUCTS, V51, P426

[5]

GUINAUDEAU H, 1994, J NAT PRODUCTS, V57, P1083

[6]

GUINAUDEAU H, 1983, J NAT PRODUCTS, V46, P807

[7] ALKALOIDS OF ANNONACEAE .37. ALKALOIDS OF GUATTERIA-SCANDENS [J].

HOCQUEMILLER, R ;

RASAMIZAFY, S ;

CAVE, A ;

MORETTI, C .

JOURNAL OF NATURAL PRODUCTS, 1983, 46 (03) :335-341

[8] A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates [J].

Holt, A ;

Sharman, DF ;

Baker, GB ;

Palcic, MM .

ANALYTICAL BIOCHEMISTRY, 1997, 244 (02) :384-392

[9] Alkaloids and volatile constituents from Guatteria juruensis [J].

Lima, MA ;

Fechine, IM ;

Silva, MS ;

Maia, JGS ;

da-Cunha, EVL ;

Barbosa, JM .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2003, 31 (04) :423-425

[10]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

← 1 2 →